Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 5550416..5550955 Replicon chromosome
Accession NZ_CP044145
Organism Escherichia coli O157 strain AR-0428

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag F4V40_RS28435 Protein ID WP_001303998.1
Coordinates 5550416..5550676 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag F4V40_RS28440 Protein ID WP_000729705.1
Coordinates 5550695..5550955 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V40_RS28420 5548099..5548677 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
F4V40_RS28425 5548782..5549549 + 768 WP_001301698.1 class II glutamine amidotransferase -
F4V40_RS28430 5549520..5550260 - 741 WP_001225679.1 murein L,D-transpeptidase -
F4V40_RS28435 5550416..5550676 - 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
F4V40_RS28440 5550695..5550955 - 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
F4V40_RS28445 5551141..5551914 + 774 WP_000543891.1 C40 family peptidase -
F4V40_RS28450 5552090..5552587 + 498 Protein_5404 REP-associated tyrosine transposase RayT -
F4V40_RS28455 5552732..5554444 - 1713 Protein_5405 flagellar biosynthesis protein FlhA -
F4V40_RS28460 5554416..5555201 + 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T140269 WP_001303998.1 NZ_CP044145:c5550676-5550416 [Escherichia coli O157]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T140269 NZ_CP059068:c1023821-1023393 [Rhodoferax sp. AJA081-3]
ATGCGCGCGCTGCTGGACATTAATGTGCTGATTGCCCTGCATGACGGGGACCATGTACACCACCAGCGCGCAGCACTTTG
GTTCGAATCCAACATCGTGCATGGCTGGGCCAGTTGCCCGCTGACACAAAACGGCTGCTTGCGCATCATGAGCCAGCCTG
GCTACAGCAGCCCGCAACCGTTGGCGGTGTTGGTATCCATGTTGCATGGCTCCACCACCACGGCTTTTCACATGTTGTGG
AGTGATGACATCAGCCTGCTGGATGCCAAGTATTTTCACCACACGCATATGCACAGCCACGGCCAGCTGACCGATTTGTA
TCTACTGGCTTTGGCTGTAAAGAATGGCGGGCGCTTGGTCAGTTTTGACCAGCGTATCCCGCTGAGTGCAGTGCATGGTG
CACGTGCAGAGCATTTGGTAAAGCTGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT140269 WP_000729705.1 NZ_CP044145:c5550955-5550695 [Escherichia coli O157]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT140269 NZ_CP059068:c1024101-1023826 [Rhodoferax sp. AJA081-3]
ATGCGTACAACCTTGGATATTGCAGACGACGTGCTTTATGCCGCCAAAGAAATTGCGCAGCGCGAGAAAAAGCCACTGGG
CACCATCATCAGCGACCTTGCACGCCGTGCCTTTCTGAATCCCGAAGGCATTACGCATGCTGCAGGGGCAACTGGTGCGG
CAGCCCCGCAAGTGTCCGAACGGTTGGCCAGCTATGGCATTCACCCCTTGCCTACGCGGGGAGGCATTGTCAGCAACGAG
CTCGTAGACCGGCTGCGCGACGCCGAGGGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References