Detailed information of TA system TA140118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-TIGR02293
• Location: 149812..150788
• Replicon: chromosome
• Accession: NZ_CP044114
• Organism: Roseomonas mucosa strain FDAARGOS_658

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: FOB66_RS00790
• Protein ID: WP_150357405.1
• Coordinates: 150303..150788 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: FOB66_RS00785
• Protein ID: WP_208852635.1
• Coordinates: 149812..150306 (+)
• Length: 165 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB66_RS00775	147111..147776	+	666	WP_167522596.1	ParA family protein	-
FOB66_RS00780	148561..149544	+	984	WP_150357403.1	pirin	-
FOB66_RS00785	149812..150306	+	495	WP_208852635.1	DUF2384 domain-containing protein	Antitoxin
FOB66_RS00790	150303..150788	+	486	WP_150357405.1	RES family NAD+ phosphorylase	Toxin
FOB66_RS00795	150892..151596	+	705	WP_167522597.1	ProQ/FinO family protein	-
FOB66_RS00800	151634..152619	+	986	Protein_160	nucleotidyltransferase domain-containing protein	-
FOB66_RS00805	152616..153386	+	771	WP_150357409.1	nucleotidyltransferase domain-containing protein	-
FOB66_RS00810	153553..153891	+	339	WP_150357411.1	type II toxin-antitoxin system PrlF family antitoxin	-
FOB66_RS00815	153934..154452	+	519	WP_150357456.1	type II toxin-antitoxin system YhaV family toxin	-
FOB66_RS00820	154493..155182	-	690	WP_167522598.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-146)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (115-161)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17856.23 Da
• Isoelectric Point: 8.0934

>T140118 WP_150357405.1 NZ_CP044114:150303-150788 [Roseomonas mucosa]
VTRAVWRIATDAPAYEADDMTGTGAKLTGGRWNERDVAVVYAAEHRSLACLETMAHLNAGGLPLNRYLVEVTIPDEIWKA
REEHDAASLPVGWDARPSSRTSIGWGTTWLRSRRTAVLVVPSVIVPEERNVIINPHHPDSAGITARKQRLWTYDPRLAKA
P

Nucleotide

• Length: 486 bp

>T140118 NZ_CP058948:3212267-3212596 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Protein

• Length: 165 a.a.
• Molecular weight: 17651.32 Da
• Isoelectric Point: 10.5197

>AT140118 WP_208852635.1 NZ_CP044114:149812-150306 [Roseomonas mucosa]
MSQLNVPADRPRRTAMRRPAGSALSYVEVFRAEPIKRINMIKHGLSAAEAKRILSDLAVTQAVAMRALNISAATMNRKVR
GEDRLPPAESERVLGIARLVGQVQAIVEESGRPEGFDAAAWTSRWLSEPLPALGGARPLDLLDTMEGQALVSSTLAHIQG
GAYA

Nucleotide

• Length: 495 bp

>AT140118 NZ_CP058948:3211929-3212246 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA