Detailed information of TA system TA140104

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 80251..80954
• Replicon: chromosome
• Accession: NZ_CP044107
• Organism: Enterobacter hormaechei strain FDAARGOS_642

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: FOB50_RS00385
• Protein ID: WP_150390672.1
• Coordinates: 80251..80616 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: FOB50_RS00390
• Protein ID: WP_150390673.1
• Coordinates: 80637..80954 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOB50_RS00355	75487..76038	+	552	WP_017383135.1	hypothetical protein	-
FOB50_RS00360	76289..77659	-	1371	WP_150390671.1	reverse transcriptase	-
FOB50_RS00365	77649..78188	-	540	WP_017383133.1	SLATT domain-containing protein	-
FOB50_RS00370	78858..79247	-	390	WP_017383132.1	hypothetical protein	-
FOB50_RS00375	79385..79573	-	189	WP_017383131.1	hypothetical protein	-
FOB50_RS00380	79726..80036	+	311	Protein_74	tyrosine-type recombinase/integrase	-
FOB50_RS00385	80251..80616	-	366	WP_150390672.1	TA system toxin CbtA family protein	Toxin
FOB50_RS00390	80637..80954	-	318	WP_150390673.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FOB50_RS00395	80972..81193	-	222	WP_150390674.1	DUF987 domain-containing protein	-
FOB50_RS00400	81202..81684	-	483	WP_150390675.1	DNA repair protein RadC	-
FOB50_RS00405	81693..82154	-	462	WP_150390676.1	antirestriction protein	-
FOB50_RS00410	82151..82348	-	198	WP_150391268.1	DUF905 family protein	-
FOB50_RS00415	82658..82792	-	135	Protein_81	arsenical resistance protein ArsH	-
FOB50_RS00420	82872..83276	-	405	WP_024195748.1	H-NS histone family protein	-
FOB50_RS00425	83804..84031	-	228	WP_016239708.1	hypothetical protein	-
FOB50_RS00430	84300..84518	-	219	WP_150390677.1	cold shock domain-containing protein	-
FOB50_RS00435	84785..84997	+	213	WP_150390678.1	cold shock-like protein CspF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13707.93 Da
• Isoelectric Point: 8.5006

>T140104 WP_150390672.1 NZ_CP044107:c80616-80251 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRNGF
TLQERTPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSR

Nucleotide

• Length: 366 bp

>T140104 NZ_CP058948:650027-650425 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11939.56 Da
• Isoelectric Point: 6.6252

>AT140104 WP_150390673.1 NZ_CP044107:c80954-80637 [Enterobacter hormaechei]
MSNTTWGLQRDITPRLEARLVQEGNRLHYLADRASITGKFSEAECLKLEVAFPHFINQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT140104 NZ_CP058948:649731-650024 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA