Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1525799..1526538 Replicon chromosome
Accession NZ_CP044083
Organism Klebsiella aerogenes strain FDAARGOS_641

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag FOB49_RS07555 Protein ID WP_015705365.1
Coordinates 1526053..1526538 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag FOB49_RS07550 Protein ID WP_015705366.1
Coordinates 1525799..1526065 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB49_RS07525 1521134..1521721 + 588 WP_015705371.1 hypothetical protein -
FOB49_RS07530 1521718..1523037 + 1320 WP_015705370.1 two-component sensor histidine kinase -
FOB49_RS07535 1523037..1523654 + 618 WP_015705369.1 response regulator transcription factor -
FOB49_RS07540 1523750..1524247 + 498 WP_015705368.1 heme-binding protein -
FOB49_RS07545 1524291..1525526 - 1236 WP_015705367.1 MFS transporter -
FOB49_RS07550 1525799..1526065 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
FOB49_RS07555 1526053..1526538 + 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
FOB49_RS07560 1526610..1528226 + 1617 WP_015705364.1 FAD-NAD(P)-binding protein -
FOB49_RS07565 1528345..1529445 + 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
FOB49_RS07570 1529502..1529660 - 159 WP_015705362.1 YqaE/Pmp3 family membrane protein -
FOB49_RS07575 1529921..1530991 + 1071 WP_015705361.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T140020 WP_015705365.1 NZ_CP044083:1526053-1526538 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T140020 NZ_CP058875:58260-58676 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT140020 WP_015705366.1 NZ_CP044083:1525799-1526065 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT140020 NZ_CP058875:58033-58263 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References