139853

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2970050..2970698 Replicon chromosome
Accession NZ_CP043997
Organism Mycobacterium tuberculosis strain 1-0066P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ49_RS13885 Protein ID WP_003899414.1
Coordinates 2970050..2970373 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ49_RS13890 Protein ID WP_003899415.1
Coordinates 2970453..2970698 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ49_RS13855 2965373..2966371 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ49_RS13860 2966385..2966849 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ49_RS13865 2966837..2967088 + 252 WP_003908028.1 hypothetical protein -
FPJ49_RS13870 2967259..2968698 - 1440 WP_003901443.1 phage major capsid protein -
FPJ49_RS13875 2968706..2969239 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ49_RS13880 2969392..2969883 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ49_RS13885 2970050..2970373 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ49_RS13890 2970453..2970698 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ49_RS13895 2970695..2972122 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ49_RS13900 2972124..2972516 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ49_RS13905 2972513..2972773 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ49_RS13910 2972790..2973152 - 363 WP_003900543.1 hypothetical protein -
FPJ49_RS13915 2973155..2974282 - 1128 WP_003899420.1 site-specific integrase -
FPJ49_RS13920 2974427..2974654 - 228 WP_003899421.1 hypothetical protein -
FPJ49_RS13925 2974651..2975040 - 390 WP_003899422.1 hypothetical protein -
FPJ49_RS13930 2974946..2975218 + 273 WP_003900544.1 hypothetical protein -
FPJ49_RS13935 2975317..2975550 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2965373..2974282 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T139853 WP_003899414.1 NZ_CP043997:c2970373-2970050 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T139853 NZ_CP058833:c4280933-4280715 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT139853 WP_003899415.1 NZ_CP043997:c2970698-2970453 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT139853 NZ_CP058833:c4281333-4280959 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References