Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3782166..3782695 Replicon chromosome
Accession NZ_CP043996
Organism Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag FPJ52_RS17630 Protein ID WP_003417760.1
Coordinates 3782438..3782695 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPJ52_RS17625 Protein ID WP_003417757.1
Coordinates 3782166..3782441 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ52_RS17605 3778964..3780401 - 1438 Protein_3477 FAD-binding oxidoreductase -
FPJ52_RS17610 3780504..3780893 + 390 WP_003417745.1 DUF732 domain-containing protein -
FPJ52_RS17615 3780907..3781200 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FPJ52_RS17620 3781197..3782042 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPJ52_RS17625 3782166..3782441 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPJ52_RS17630 3782438..3782695 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
FPJ52_RS17635 3782737..3783927 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPJ52_RS17640 3784044..3784412 + 369 WP_003417765.1 FHA domain-containing protein -
FPJ52_RS17645 3784409..3784960 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPJ52_RS17650 3784967..3785548 - 582 WP_003417769.1 ATP/GTP-binding protein -
FPJ52_RS17655 3785529..3785897 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPJ52_RS17660 3785875..3786267 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T139803 WP_003417760.1 NZ_CP043996:3782438-3782695 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T139803 NZ_CP058828:2722802-2722909 [Shigella flexneri]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT139803 WP_003417757.1 NZ_CP043996:3782166-3782441 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT139803 NZ_CP058828:c2722755-2722689 [Shigella flexneri]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References