Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3138744..3139348 Replicon chromosome
Accession NZ_CP043996
Organism Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag FPJ52_RS14840 Protein ID WP_003414492.1
Coordinates 3138744..3139136 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag FPJ52_RS14845 Protein ID WP_003414495.1
Coordinates 3139133..3139348 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ52_RS14810 3133894..3134682 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
FPJ52_RS14815 3135016..3135561 - 546 WP_014584866.1 DUF1802 family protein -
FPJ52_RS14820 3135833..3136717 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FPJ52_RS14825 3136720..3137607 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
FPJ52_RS14830 3137912..3138457 - 546 WP_003910939.1 DUF1802 family protein -
FPJ52_RS14835 3138454..3138723 - 270 WP_003414489.1 DUF2277 family protein -
FPJ52_RS14840 3138744..3139136 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ52_RS14845 3139133..3139348 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPJ52_RS14850 3139395..3140144 + 750 WP_003902358.1 enoyl-CoA hydratase -
FPJ52_RS14855 3140223..3141305 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
FPJ52_RS14860 3141298..3142608 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
FPJ52_RS14865 3142611..3143438 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
FPJ52_RS14870 3143435..3144346 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T139798 WP_003414492.1 NZ_CP043996:c3139136-3138744 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T139798 NZ_CP058828:1830416-1830670 [Shigella flexneri]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAATCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT139798 WP_003414495.1 NZ_CP043996:c3139348-3139133 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT139798 NZ_CP058828:1830168-1830419 [Shigella flexneri]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References