Detailed information of TA system TA139790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 2869256..2869887
• Replicon: chromosome
• Accession: NZ_CP043996
• Organism: Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ52_RS13340
• Protein ID: WP_192948130.1
• Coordinates: 2869510..2869887 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P95006
• Locus tag: FPJ52_RS13335
• Protein ID: WP_003413167.1
• Coordinates: 2869256..2869513 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ52_RS13305	2865171..2865485	+	315	WP_009937839.1	hypothetical protein	-
FPJ52_RS13310	2865781..2866992	+	1212	WP_003900845.1	alpha/beta hydrolase family protein	-
FPJ52_RS13315	2867119..2867778	+	660	WP_003902296.1	hypothetical protein	-
FPJ52_RS13320	2867775..2868437	+	663	WP_031729659.1	hypothetical protein	-
FPJ52_RS13325	2868434..2868711	+	278	Protein_2630	type II toxin-antitoxin system VapB family antitoxin	-
FPJ52_RS13330	2868804..2869217	+	414	WP_003413164.1	PIN domain nuclease	-
FPJ52_RS13335	2869256..2869513	+	258	WP_003413167.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPJ52_RS13340	2869510..2869887	+	378	WP_192948130.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ52_RS13345	2869903..2870277	-	375	WP_003413177.1	hypothetical protein	-
FPJ52_RS13350	2870377..2870772	-	396	WP_003413180.1	type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20	-
FPJ52_RS13355	2870769..2871014	-	246	WP_003413183.1	type II toxin-antitoxin system antitoxin VapB20	-
FPJ52_RS13360	2871425..2871844	-	420	WP_003413190.1	A24 family peptidase	-
FPJ52_RS13365	2871856..2872665	-	810	WP_003413193.1	shikimate dehydrogenase	-
FPJ52_RS13370	2872662..2873915	-	1254	WP_003413196.1	endolytic transglycosylase MltG	-
FPJ52_RS13375	2873908..2874420	-	513	WP_003413197.1	Holliday junction resolvase RuvX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13750.77 Da
• Isoelectric Point: 4.7182

>T139790 WP_192948130.1 NZ_CP043996:2869510-2869887 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEHIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Nucleotide

• Length: 378 bp

>T139790 NZ_CP058827:c759-478 [Shigella flexneri]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9453.63 Da
• Isoelectric Point: 10.6555

>AT139790 WP_003413167.1 NZ_CP043996:2869256-2869513 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Nucleotide

• Length: 258 bp

>AT139790 NZ_CP058827:c1000-749 [Shigella flexneri]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A829C9W5