Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2403433..2403962 Replicon chromosome
Accession NZ_CP043996
Organism Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FPJ52_RS11155 Protein ID WP_003411124.1
Coordinates 2403433..2403750 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FPJ52_RS11160 Protein ID WP_003411127.1
Coordinates 2403747..2403962 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ52_RS11125 2398454..2399530 + 1077 WP_003411110.1 hypothetical protein -
FPJ52_RS11130 2399527..2399808 + 282 WP_003411112.1 hypothetical protein -
FPJ52_RS11135 2399844..2400917 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
FPJ52_RS11140 2400922..2401452 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FPJ52_RS11145 2401500..2402846 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FPJ52_RS11155 2403433..2403750 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ52_RS11160 2403747..2403962 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FPJ52_RS11165 2404217..2405275 + 1059 WP_003411129.1 hypothetical protein -
FPJ52_RS11170 2405405..2405761 - 357 WP_003411130.1 hypothetical protein -
FPJ52_RS11175 2405856..2406638 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FPJ52_RS11180 2406906..2407196 - 291 WP_003900476.1 YggT family protein -
FPJ52_RS11185 2407358..2408014 - 657 WP_003411133.1 cell division protein SepF -
FPJ52_RS11190 2408076..2408855 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T139786 WP_003411124.1 NZ_CP043996:c2403750-2403433 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T139786 NZ_CP058826:3512813-3513091 [Shigella flexneri]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT139786 WP_003411127.1 NZ_CP043996:c2403962-2403747 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT139786 NZ_CP058826:3512550-3512810 [Shigella flexneri]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References