Detailed information of TA system TA139778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2193019..2193563
• Replicon: chromosome
• Accession: NZ_CP043996
• Organism: Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TLU9
• Locus tag: FPJ52_RS10135
• Protein ID: WP_003409896.1
• Coordinates: 2193019..2193315 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P67299
• Locus tag: FPJ52_RS10140
• Protein ID: WP_003409899.1
• Coordinates: 2193312..2193563 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ52_RS10080	2188052..2188402	-	351	WP_003409871.1	hypothetical protein	-
FPJ52_RS10085	2188413..2189315	-	903	WP_003899097.1	hypothetical protein	-
FPJ52_RS10090	2189336..2189527	-	192	WP_003409876.1	hypothetical protein	-
FPJ52_RS10095	2189528..2189824	-	297	WP_003409877.1	hypothetical protein	-
FPJ52_RS10100	2190064..2190279	+	216	WP_003409878.1	antitoxin	-
FPJ52_RS10105	2190276..2190587	+	312	WP_003409881.1	type II toxin-antitoxin system VapC family toxin	-
FPJ52_RS10110	2190561..2191082	-	522	WP_003904745.1	hypothetical protein	-
FPJ52_RS10115	2191057..2191434	+	378	WP_010886136.1	type II toxin-antitoxin system toxin HigB	-
FPJ52_RS10120	2191476..2191925	+	450	WP_003409886.1	type II toxin-antitoxin system antitoxin HigA	-
FPJ52_RS10125	2191922..2192467	+	546	WP_003409891.1	SecB-like chaperone	-
FPJ52_RS10130	2192356..2192970	-	615	WP_003901296.1	hypothetical protein	-
FPJ52_RS10135	2193019..2193315	-	297	WP_003409896.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FPJ52_RS10140	2193312..2193563	-	252	WP_003409899.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FPJ52_RS10145	2193550..2194044	+	495	WP_003899099.1	hypothetical protein	-
FPJ52_RS10150	2194204..2194611	-	408	WP_003409913.1	type II toxin-antitoxin system VapC family toxin	-
FPJ52_RS10155	2194615..2194887	-	273	WP_003899100.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FPJ52_RS10160	2194920..2196140	-	1221	WP_003409919.1	TetR family transcriptional regulator Mce3R	-
FPJ52_RS10165	2197039..2197836	+	798	WP_003899101.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (2-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11268.64 Da
• Isoelectric Point: 6.8604

>T139778 WP_003409896.1 NZ_CP043996:c2193315-2193019 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Nucleotide

• Length: 297 bp

>T139778 NZ_CP058826:1997485-1997588 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9207.17 Da
• Isoelectric Point: 7.0150

>AT139778 WP_003409899.1 NZ_CP043996:c2193563-2193312 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Nucleotide

• Length: 252 bp

>AT139778 NZ_CP058826:c1997626-1997355 [Shigella flexneri]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: G0TLU9

Antitoxin

• AlphaFold DB: A0A7U4BUZ2