Detailed information of TA system TA139769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1389922..1390481
• Replicon: chromosome
• Accession: NZ_CP043996
• Organism: Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: FPJ52_RS06525
• Protein ID: WP_003898789.1
• Coordinates: 1389922..1390215 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FPJ52_RS06530
• Protein ID: WP_003406322.1
• Coordinates: 1390212..1390481 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ52_RS06500	1385620..1385880	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FPJ52_RS06505	1385877..1386308	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FPJ52_RS06510	1386331..1387914	-	1584	WP_009940130.1	PE family protein	-
FPJ52_RS06515	1388094..1388954	+	861	WP_003900301.1	hypothetical protein	-
FPJ52_RS06520	1389035..1389865	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPJ52_RS06525	1389922..1390215	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FPJ52_RS06530	1390212..1390481	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FPJ52_RS06535	1390594..1394289	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FPJ52_RS06540	1394431..1395219	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T139769 WP_003898789.1 NZ_CP043996:c1390215-1389922 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T139769 NZ_CP058797:30881-31162 [Shigella flexneri]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT139769 WP_003406322.1 NZ_CP043996:c1390481-1390212 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT139769 NZ_CP058797:30640-30891 [Shigella flexneri]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2