Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1385620..1386308 Replicon chromosome
Accession NZ_CP043996
Organism Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag FPJ52_RS06505 Protein ID WP_003406304.1
Coordinates 1385877..1386308 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag FPJ52_RS06500 Protein ID WP_003406302.1
Coordinates 1385620..1385880 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ52_RS06480 1381197..1382021 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
FPJ52_RS06485 1382026..1383207 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
FPJ52_RS06490 1383284..1384384 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
FPJ52_RS06495 1384555..1385544 + 990 WP_003406301.1 malate dehydrogenase -
FPJ52_RS06500 1385620..1385880 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
FPJ52_RS06505 1385877..1386308 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ52_RS06510 1386331..1387914 - 1584 WP_009940130.1 PE family protein -
FPJ52_RS06515 1388094..1388954 + 861 WP_003900301.1 hypothetical protein -
FPJ52_RS06520 1389035..1389865 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
FPJ52_RS06525 1389922..1390215 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
FPJ52_RS06530 1390212..1390481 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T139768 WP_003406304.1 NZ_CP043996:1385877-1386308 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

>T139768 NZ_CP058796:3790027-3790305 [Shigella flexneri]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT139768 WP_003406302.1 NZ_CP043996:1385620-1385880 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp

>AT139768 NZ_CP058796:3789764-3790024 [Shigella flexneri]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References