Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709095..709720 Replicon chromosome
Accession NZ_CP043996
Organism Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FPJ52_RS03210 Protein ID WP_003403218.1
Coordinates 709319..709720 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FPJ52_RS03205 Protein ID WP_003403213.1
Coordinates 709095..709322 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ52_RS03180 704274..704495 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FPJ52_RS03185 704637..705242 + 606 WP_003898526.1 hypothetical protein -
FPJ52_RS03190 705261..707828 - 2568 WP_003901879.1 SEC-C domain-containing protein -
FPJ52_RS03195 707912..708661 + 750 WP_003898528.1 hypothetical protein -
FPJ52_RS03200 708658..708900 + 243 WP_003403210.1 hypothetical protein -
FPJ52_RS03205 709095..709322 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FPJ52_RS03210 709319..709720 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FPJ52_RS03215 709849..710544 + 696 WP_003900189.1 galactose-1-phosphate uridylyltransferase -
FPJ52_RS03220 710541..711032 + 492 WP_192948149.1 galactose-1-phosphate uridylyltransferase -
FPJ52_RS03225 711029..712120 + 1092 WP_003900977.1 galactokinase -
FPJ52_RS03230 712515..713579 + 1065 WP_003898532.1 hypothetical protein -
FPJ52_RS03235 713683..714630 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T139756 WP_003403218.1 NZ_CP043996:709319-709720 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T139756 NZ_CP058796:c1860553-1860179 [Shigella flexneri]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT139756 WP_003403213.1 NZ_CP043996:709095-709322 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT139756 NZ_CP058796:c1861010-1860642 [Shigella flexneri]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References