Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2520630..2521288 Replicon chromosome
Accession NZ_CP043955
Organism Morganella morganii subsp. morganii strain 171229813

Toxin (Protein)


Gene name higB Uniprot ID A0A447J593
Locus tag F3L16_RS12575 Protein ID WP_032098584.1
Coordinates 2520935..2521288 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J7TDD0
Locus tag F3L16_RS12570 Protein ID WP_004236876.1
Coordinates 2520630..2520932 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3L16_RS12530 2516996..2517691 - 696 WP_004240015.1 MgtC family protein -
F3L16_RS12535 2518041..2518235 - 195 WP_015422621.1 protein DsrB -
F3L16_RS12540 2518339..2518551 - 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
F3L16_RS12545 2519012..2519521 + 510 WP_004240013.1 YlaC family protein -
F3L16_RS12570 2520630..2520932 - 303 WP_004236876.1 XRE family transcriptional regulator Antitoxin
F3L16_RS12575 2520935..2521288 - 354 WP_032098584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F3L16_RS12580 2521565..2522617 + 1053 WP_062772495.1 dihydroorotase -
F3L16_RS12585 2522852..2523109 + 258 WP_004236879.1 biofilm formation regulator BssS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.58 Da        Isoelectric Point: 9.9631

>T139676 WP_032098584.1 NZ_CP043955:c2521288-2520935 [Morganella morganii subsp. morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T139676 NZ_CP058780:166274-166381 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11108.00 Da        Isoelectric Point: 9.5930

>AT139676 WP_004236876.1 NZ_CP043955:c2520932-2520630 [Morganella morganii subsp. morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT139676 NZ_CP058780:c166217-166160 [Shigella flexneri]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447J593

Antitoxin

Source ID Structure
AlphaFold DB J7TDD0

References