Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1207995..1208656 Replicon chromosome
Accession NZ_CP043955
Organism Morganella morganii subsp. morganii strain 171229813

Toxin (Protein)


Gene name ypjF Uniprot ID S3IMJ6
Locus tag F3L16_RS05545 Protein ID WP_000698542.1
Coordinates 1208333..1208656 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID S3J179
Locus tag F3L16_RS05540 Protein ID WP_000065326.1
Coordinates 1207995..1208312 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3L16_RS05495 1203135..1203959 + 825 WP_000197385.1 DUF945 domain-containing protein -
F3L16_RS05500 1204168..1204878 + 711 WP_024198336.1 hypothetical protein -
F3L16_RS05505 1204904..1205440 + 537 WP_000219797.1 DUF4339 domain-containing protein -
F3L16_RS05510 1205482..1205919 + 438 WP_024198335.1 hypothetical protein -
F3L16_RS05515 1205986..1206396 + 411 WP_000912997.1 hypothetical protein -
F3L16_RS05520 1206474..1206710 + 237 WP_000004273.1 DUF905 domain-containing protein -
F3L16_RS05525 1206796..1207254 + 459 WP_016538084.1 antirestriction protein -
F3L16_RS05530 1207270..1207746 + 477 WP_000811694.1 RadC family protein -
F3L16_RS05535 1207755..1207976 + 222 WP_000691995.1 DUF987 domain-containing protein -
F3L16_RS05540 1207995..1208312 + 318 WP_000065326.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F3L16_RS05545 1208333..1208656 + 324 WP_000698542.1 TA system toxin CbtA family protein Toxin
F3L16_RS05550 1209492..1209599 + 108 WP_107678959.1 leader peptide SpeFL -
F3L16_RS05555 1209979..1212141 + 2163 WP_015422912.1 ornithine decarboxylase SpeF -
F3L16_RS05560 1212205..1213533 + 1329 WP_032098853.1 putrescine-ornithine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1178496..1208656 30160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.38 Da        Isoelectric Point: 8.9789

>T139675 WP_000698542.1 NZ_CP043955:1208333-1208656 [Morganella morganii subsp. morganii]
MKILPATISRAAKPCLPPVAVWQLLLTRLLEKHYGLTLNDTPFSDETVIKEHFDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTNIDIMRARRDLGLLNRN

Download         Length: 324 bp

>T139675 NZ_CP058780:165791-165898 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11830.50 Da        Isoelectric Point: 6.9367

>AT139675 WP_000065326.1 NZ_CP043955:1207995-1208312 [Morganella morganii subsp. morganii]
MSNIIWGLQRDITPRLGTRLVQEGNQLHYLADRACITGKFSDAECLKLDVAFPHFISRMESMLSTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYVAVYSTQR

Download         Length: 318 bp

>AT139675 NZ_CP058780:c165733-165677 [Shigella flexneri]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3IMJ6

Antitoxin

Source ID Structure
AlphaFold DB S3J179

References