Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3132053..3132884 Replicon chromosome
Accession NZ_CP043950
Organism Escherichia coli strain ST95-32

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag F3J96_RS15750 Protein ID WP_000854814.1
Coordinates 3132510..3132884 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag F3J96_RS15745 Protein ID WP_001285586.1
Coordinates 3132053..3132421 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3J96_RS15705 3127270..3128340 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
F3J96_RS15710 3128476..3129153 + 678 WP_001362823.1 hypothetical protein -
F3J96_RS15715 3129169..3129579 + 411 WP_000846704.1 hypothetical protein -
F3J96_RS15725 3129800..3130621 + 822 WP_001234569.1 DUF945 domain-containing protein -
F3J96_RS15730 3130712..3131197 + 486 WP_000213703.1 antirestriction protein -
F3J96_RS15735 3131213..3131689 + 477 WP_001351157.1 RadC family protein -
F3J96_RS15740 3131758..3131979 + 222 WP_000692323.1 DUF987 domain-containing protein -
F3J96_RS15745 3132053..3132421 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
F3J96_RS15750 3132510..3132884 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
F3J96_RS15755 3132881..3133075 + 195 WP_000988601.1 hypothetical protein -
F3J96_RS15760 3133088..3133201 + 114 WP_001161660.1 DUF957 domain-containing protein -
F3J96_RS15765 3133490..3133636 - 147 Protein_2997 transposase domain-containing protein -
F3J96_RS15770 3133690..3133872 + 183 WP_001016348.1 hypothetical protein -
F3J96_RS15775 3133973..3134302 - 330 WP_000450409.1 DUF496 family protein -
F3J96_RS15780 3134474..3135532 - 1059 WP_001200890.1 FUSC family protein -
F3J96_RS15785 3135730..3136203 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
F3J96_RS15790 3136322..3137488 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T139649 WP_000854814.1 NZ_CP043950:3132510-3132884 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T139649 NZ_CP058771:266370-266477 [Shigella flexneri]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT139649 WP_001285586.1 NZ_CP043950:3132053-3132421 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT139649 NZ_CP058771:c266322-266256 [Shigella flexneri]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References