Detailed information of TA system TA139618

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 721347..721759
• Replicon: chromosome
• Accession: NZ_CP043950
• Organism: Escherichia coli strain ST95-32

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: F3J96_RS03665
• Protein ID: WP_150330589.1
• Coordinates: 721347..721688 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	721683..721759 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3J96_RS03645	716416..717696	-	1281	WP_001338077.1	DUF445 domain-containing protein	-
F3J96_RS03650	717881..718801	+	921	WP_001513532.1	Rpn family recombination-promoting nuclease/putative transposase	-
F3J96_RS03655	719029..719109	+	81	WP_020233658.1	hypothetical protein	-
F3J96_RS03660	719144..721300	+	2157	WP_001513533.1	DUF262 domain-containing protein	-
F3J96_RS03665	721347..721688	-	342	WP_150330589.1	endoribonuclease SymE	Toxin
-	721683..721759	+	77	NuclAT_6	-	Antitoxin
-	721683..721759	+	77	NuclAT_6	-	Antitoxin
-	721683..721759	+	77	NuclAT_6	-	Antitoxin
-	721683..721759	+	77	NuclAT_6	-	Antitoxin
-	721683..721759	+	77	NuclAT_7	-	Antitoxin
-	721683..721759	+	77	NuclAT_7	-	Antitoxin
-	721683..721759	+	77	NuclAT_7	-	Antitoxin
-	721683..721759	+	77	NuclAT_7	-	Antitoxin
F3J96_RS03670	721909..723678	-	1770	WP_001513535.1	restriction endonuclease subunit S	-
F3J96_RS03675	723678..725147	-	1470	WP_001387312.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12290.05 Da
• Isoelectric Point: 8.5043

>T139618 WP_150330589.1 NZ_CP043950:c721688-721347 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASHYPDYSRIPAITLKGQWREAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T139618 NZ_CP058752:2641747-2641965 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT139618 NZ_CP043950:721683-721759 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin