Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2673426..2674080 Replicon chromosome
Accession NZ_CP043852
Organism Escherichia coli ATCC 8739

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag F1719_RS13395 Protein ID WP_000244783.1
Coordinates 2673426..2673833 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag F1719_RS13400 Protein ID WP_000354046.1
Coordinates 2673814..2674080 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1719_RS13375 2669383..2671116 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
F1719_RS13380 2671122..2671832 - 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F1719_RS13385 2671857..2672753 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
F1719_RS13390 2672865..2673386 + 522 WP_001055874.1 flavodoxin FldB -
F1719_RS13395 2673426..2673833 - 408 WP_000244783.1 protein YgfX Toxin
F1719_RS13400 2673814..2674080 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
F1719_RS13405 2674323..2675303 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
F1719_RS13410 2675499..2676158 - 660 WP_000250274.1 hemolysin III family protein -
F1719_RS13415 2676322..2676633 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
F1719_RS13420 2676678..2678111 + 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
F1719_RS13425 2678168..2678910 - 743 Protein_2507 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T139394 WP_000244783.1 NZ_CP043852:c2673833-2673426 [Escherichia coli ATCC 8739]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T139394 NZ_CP058661:c4602472-4602065 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT139394 WP_000354046.1 NZ_CP043852:c2674080-2673814 [Escherichia coli ATCC 8739]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT139394 NZ_CP058661:c4602719-4602453 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References