Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 7416925..7417510 Replicon chromosome
Accession NZ_CP043661
Organism Kribbella qitaiheensis strain SPB151

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag F1D05_RS35165 Protein ID WP_185444581.1
Coordinates 7416925..7417233 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag F1D05_RS35170 Protein ID WP_185444582.1
Coordinates 7417238..7417510 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1D05_RS35150 7412081..7413937 - 1857 WP_185444578.1 DNA helicase RecQ -
F1D05_RS35155 7414076..7414909 - 834 WP_185444579.1 helix-turn-helix domain-containing protein -
F1D05_RS35160 7415073..7416923 + 1851 WP_185444580.1 dihydroxy-acid dehydratase -
F1D05_RS35165 7416925..7417233 - 309 WP_185444581.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F1D05_RS35170 7417238..7417510 - 273 WP_185444582.1 antitoxin Antitoxin
F1D05_RS35175 7417560..7418228 - 669 WP_185444583.1 LON peptidase substrate-binding domain-containing protein -
F1D05_RS35180 7418350..7419669 + 1320 WP_206686440.1 histidinol dehydrogenase -
F1D05_RS35185 7419662..7420780 + 1119 WP_185444585.1 histidinol-phosphate transaminase -
F1D05_RS35190 7420777..7421376 + 600 WP_185444586.1 imidazoleglycerol-phosphate dehydratase HisB -
F1D05_RS35195 7421373..7422014 + 642 WP_185444587.1 imidazole glycerol phosphate synthase subunit HisH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11219.06 Da        Isoelectric Point: 7.1663

>T139176 WP_185444581.1 NZ_CP043661:c7417233-7416925 [Kribbella qitaiheensis]
MRPIHIARLDKPRPVVVLTRELIRPRLTNVTVAPITSTIRGLSTEVLVGTRNGLDHPSAVSCDNIQTIPKVQLGRLIGYL
FPDQEPALAEAITLAFDLEAEQ

Download         Length: 309 bp

>T139176 NZ_CP058548:c1724753-1724385 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9752.93 Da        Isoelectric Point: 4.3108

>AT139176 WP_185444582.1 NZ_CP043661:c7417510-7417238 [Kribbella qitaiheensis]
MSKQITVRLPDELVEFMDQLVGDNKAASRASVVARAMERERRRELAARDLAILSEHGDYPDLEGLADAAAGTALSDLERP
AGTTVLSDLD

Download         Length: 273 bp

>AT139176 NZ_CP058548:c1724971-1724750 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References