Detailed information of TA system TA138888

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3149082..3149607
• Replicon: chromosome
• Accession: NZ_CP043497
• Organism: Streptomyces rimosus subsp. rimosus strain SRI-4018v0

Toxin (Protein)

• Gene name: relE
• Uniprot ID: L8EGB8
• Locus tag: FMM49_RS14530
• Protein ID: WP_003987428.1
• Coordinates: 3149344..3149607 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L8ED57
• Locus tag: FMM49_RS14525
• Protein ID: WP_003987429.1
• Coordinates: 3149082..3149351 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FMM49_RS14500 (FMM49_14555)	3144115..3144837	+	723	WP_030181983.1	PIG-L deacetylase family protein	-
FMM49_RS14505 (FMM49_14560)	3144825..3145793	-	969	WP_003982326.1	alpha/beta hydrolase	-
FMM49_RS14510 (FMM49_14565)	3145923..3146432	+	510	WP_003982327.1	hypothetical protein	-
FMM49_RS14515 (FMM49_14570)	3146473..3147057	+	585	WP_003982328.1	Uma2 family endonuclease	-
FMM49_RS14520 (FMM49_14575)	3147099..3148778	-	1680	WP_076611972.1	IS1182-like element ISSdi1 family transposase	-
FMM49_RS14525 (FMM49_14580)	3149082..3149351	+	270	WP_003987429.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FMM49_RS14530 (FMM49_14585)	3149344..3149607	+	264	WP_003987428.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FMM49_RS14535 (FMM49_14590)	3149742..3150830	-	1089	WP_003987427.1	redox-regulated ATPase YchF	-
FMM49_RS14540 (FMM49_14595)	3151373..3152080	+	708	WP_063604328.1	hypothetical protein	-
FMM49_RS14545 (FMM49_14600)	3152046..3152918	-	873	WP_078586864.1	ROK family protein	-
FMM49_RS14550 (FMM49_14605)	3153004..3154047	-	1044	WP_078586862.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3147099..3148778	1679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-56)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10084.54 Da
• Isoelectric Point: 8.5041

>T138888 WP_003987428.1 NZ_CP043497:3149344-3149607 [Streptomyces rimosus subsp. rimosus]
VSEYRTVFRPEAQTELRKVPRDMALRILAKLTELETDPLGFNTTALVSQPDRRRLRVGDYRLIYTIDNGELVVWVVHVGH
RSTVYDA

Nucleotide

• Length: 264 bp

>T138888 NZ_CP043497:3149344-3149607 [Streptomyces rimosus subsp. rimosus]
GTGAGTGAGTACCGCACCGTCTTCCGCCCCGAGGCTCAGACCGAACTCCGCAAGGTCCCGCGAGACATGGCTCTCCGCAT
TCTGGCGAAGCTGACCGAGTTGGAGACCGACCCGCTGGGGTTCAACACCACCGCCCTCGTCTCCCAGCCCGACCGCCGAC
GCCTACGAGTGGGTGACTACCGCCTGATCTACACGATCGACAACGGCGAGCTGGTGGTGTGGGTGGTACACGTCGGGCAT
CGCTCCACCGTCTACGACGCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10290.73 Da
• Isoelectric Point: 4.7473

>AT138888 WP_003987429.1 NZ_CP043497:3149082-3149351 [Streptomyces rimosus subsp. rimosus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIETLRKYQEWEEREINRIIDERMANPAPGIPLEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT138888 NZ_CP058253:507853-508095 [Enterobacter roggenkampii]
ATGGCCACGCTAAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCGGTGCGATTGCTGTTTCAGTACGTTGCTGAAACGGGGCGCATGCCGGTGAAAACGGTCACCATCAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATAAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: L8EGB8

Antitoxin

• AlphaFold DB: L8ED57