Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2041056..2041891 Replicon chromosome
Accession NZ_CP043414
Organism Escherichia coli strain EC42405

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag FZN31_RS09615 Protein ID WP_000854752.1
Coordinates 2041056..2041433 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag FZN31_RS09620 Protein ID WP_001278232.1
Coordinates 2041523..2041891 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZN31_RS09590 2037313..2038821 + 1509 WP_001474883.1 group II intron reverse transcriptase/maturase -
FZN31_RS09595 2038911..2039384 + 474 Protein_1878 IS3 family transposase -
FZN31_RS24870 2039543..2039914 - 372 WP_001295631.1 IS110 family transposase -
FZN31_RS09605 2040730..2040843 - 114 WP_001161660.1 DUF957 domain-containing protein -
FZN31_RS09610 2040856..2041059 - 204 WP_000761705.1 hypothetical protein -
FZN31_RS09615 2041056..2041433 - 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
FZN31_RS09620 2041523..2041891 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FZN31_RS09625 2042054..2042275 - 222 WP_000692318.1 DUF987 domain-containing protein -
FZN31_RS09630 2042338..2042814 - 477 WP_001186774.1 RadC family protein -
FZN31_RS09635 2042830..2043315 - 486 WP_000849582.1 antirestriction protein -
FZN31_RS09640 2043370..2044188 - 819 WP_001234620.1 DUF945 domain-containing protein -
FZN31_RS09645 2044288..2044521 - 234 WP_001119729.1 DUF905 family protein -
FZN31_RS09650 2044600..2045055 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T138722 WP_000854752.1 NZ_CP043414:c2041433-2041056 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T138722 NZ_CP043414:c2041433-2041056 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCCCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT138722 WP_001278232.1 NZ_CP043414:c2041891-2041523 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT138722 NZ_CP058217:c3015715-3015341 [Escherichia coli Nissle 1917]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References