Detailed information of TA system TA138418

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3775444..3776159
• Replicon: chromosome
• Accession: NZ_CP043342
• Organism: Enterobacter huaxiensis strain 090008 = WCHEHu090008

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: D5067_RS18065
• Protein ID: WP_119935361.1
• Coordinates: 3775444..3775812 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: D5067_RS18070
• Protein ID: WP_119935362.1
• Coordinates: 3775833..3776159 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5067_RS18040 (D5067_0018170)	3770948..3772732	+	1785	WP_119935357.1	diguanylate cyclase	-
D5067_RS18045 (D5067_0018180)	3773084..3773341	+	258	WP_119935358.1	YjhX family toxin	-
D5067_RS18050 (D5067_0018185)	3773351..3774061	+	711	WP_119935359.1	methyltransferase domain-containing protein	-
D5067_RS18055 (D5067_0018190)	3774134..3774754	-	621	WP_119935360.1	LysE family translocator	-
D5067_RS18060 (D5067_0018195)	3774910..3775173	-	264	WP_125914537.1	hypothetical protein	-
D5067_RS18065 (D5067_0018200)	3775444..3775812	-	369	WP_119935361.1	TA system toxin CbtA family protein	Toxin
D5067_RS18070 (D5067_0018205)	3775833..3776159	-	327	WP_119935362.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
D5067_RS18075 (D5067_0018210)	3776172..3776642	-	471	WP_119935363.1	DNA repair protein RadC	-
D5067_RS18080 (D5067_0018215)	3776712..3777533	-	822	WP_119935364.1	DUF932 domain-containing protein	-
D5067_RS18085 (D5067_0018220)	3777982..3778173	-	192	WP_090048325.1	hypothetical protein	-
D5067_RS18090 (D5067_0018225)	3778232..3779071	-	840	WP_119935365.1	hypothetical protein	-
D5067_RS18095 (D5067_0018230)	3779131..3779565	-	435	WP_119935366.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3775444..3804755	29311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13870.92 Da
• Isoelectric Point: 7.7992

>T138418 WP_119935361.1 NZ_CP043342:c3775812-3775444 [Enterobacter huaxiensis]
MKFLPATNLRAARPCLSPVTIWKMLLSRLLEQHYGLTLNDTPFYDETVIQEHIDADITLANAINFLVEKYELARIDRSGF
SSQGQAPYLTVTDIHHARKACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T138418 NZ_CP057722:334939-335307 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12176.86 Da
• Isoelectric Point: 6.3615

>AT138418 WP_119935362.1 NZ_CP043342:c3776159-3775833 [Enterobacter huaxiensis]
MSLIPAHEWGLKSDIVPRFGARLVQEGNRLHYLADRASLIGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 327 bp

>AT138418 NZ_CP057722:334721-334942 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA