Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3775444..3776159 Replicon chromosome
Accession NZ_CP043342
Organism Enterobacter huaxiensis strain 090008 = WCHEHu090008

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag D5067_RS18065 Protein ID WP_119935361.1
Coordinates 3775444..3775812 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag D5067_RS18070 Protein ID WP_119935362.1
Coordinates 3775833..3776159 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5067_RS18040 (D5067_0018170) 3770948..3772732 + 1785 WP_119935357.1 diguanylate cyclase -
D5067_RS18045 (D5067_0018180) 3773084..3773341 + 258 WP_119935358.1 YjhX family toxin -
D5067_RS18050 (D5067_0018185) 3773351..3774061 + 711 WP_119935359.1 methyltransferase domain-containing protein -
D5067_RS18055 (D5067_0018190) 3774134..3774754 - 621 WP_119935360.1 LysE family translocator -
D5067_RS18060 (D5067_0018195) 3774910..3775173 - 264 WP_125914537.1 hypothetical protein -
D5067_RS18065 (D5067_0018200) 3775444..3775812 - 369 WP_119935361.1 TA system toxin CbtA family protein Toxin
D5067_RS18070 (D5067_0018205) 3775833..3776159 - 327 WP_119935362.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
D5067_RS18075 (D5067_0018210) 3776172..3776642 - 471 WP_119935363.1 DNA repair protein RadC -
D5067_RS18080 (D5067_0018215) 3776712..3777533 - 822 WP_119935364.1 DUF932 domain-containing protein -
D5067_RS18085 (D5067_0018220) 3777982..3778173 - 192 WP_090048325.1 hypothetical protein -
D5067_RS18090 (D5067_0018225) 3778232..3779071 - 840 WP_119935365.1 hypothetical protein -
D5067_RS18095 (D5067_0018230) 3779131..3779565 - 435 WP_119935366.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3775444..3804755 29311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13870.92 Da        Isoelectric Point: 7.7992

>T138418 WP_119935361.1 NZ_CP043342:c3775812-3775444 [Enterobacter huaxiensis]
MKFLPATNLRAARPCLSPVTIWKMLLSRLLEQHYGLTLNDTPFYDETVIQEHIDADITLANAINFLVEKYELARIDRSGF
SSQGQAPYLTVTDIHHARKACGLMNSCSYREVSNIVLSRSRQ

Download         Length: 369 bp

>T138418 NZ_CP057722:334939-335307 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12176.86 Da        Isoelectric Point: 6.3615

>AT138418 WP_119935362.1 NZ_CP043342:c3776159-3775833 [Enterobacter huaxiensis]
MSLIPAHEWGLKSDIVPRFGARLVQEGNRLHYLADRASLIGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp

>AT138418 NZ_CP057722:334721-334942 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References