Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2870544..2871384 Replicon chromosome
Accession NZ_CP043284
Organism Escherichia coli strain WCHEC025985

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag FYK42_RS14085 Protein ID WP_000854686.1
Coordinates 2870544..2870927 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0YJ34
Locus tag FYK42_RS14090 Protein ID WP_001360163.1
Coordinates 2871004..2871384 (-) Length 127 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK42_RS14045 (2865546) 2865546..2866037 - 492 WP_001297187.1 DUF1097 domain-containing protein -
FYK42_RS14050 (2866139) 2866139..2866693 - 555 WP_001001902.1 molecular chaperone YcdY -
FYK42_RS14055 (2866717) 2866717..2867454 - 738 WP_000283664.1 zinc-binding phosphatase -
FYK42_RS14060 (2867509) 2867509..2868447 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
FYK42_RS14070 (2868918) 2868918..2869760 - 843 WP_001274547.1 DUF4942 domain-containing protein -
FYK42_RS14075 (2869845) 2869845..2870042 - 198 WP_000839253.1 DUF957 domain-containing protein -
FYK42_RS14080 (2870059) 2870059..2870547 - 489 WP_001054233.1 DUF5983 family protein -
FYK42_RS14085 (2870544) 2870544..2870927 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
FYK42_RS14090 (2871004) 2871004..2871384 - 381 WP_001360163.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FYK42_RS14095 (2871395) 2871395..2872078 - 684 WP_000086769.1 hypothetical protein -
FYK42_RS14100 (2872097) 2872097..2872318 - 222 WP_000692298.1 DUF987 domain-containing protein -
FYK42_RS14105 (2872381) 2872381..2872857 - 477 WP_001186726.1 RadC family protein -
FYK42_RS14110 (2872873) 2872873..2873319 - 447 WP_241408118.1 antirestriction protein -
FYK42_RS14115 (2873333) 2873333..2873769 - 437 Protein_2770 ESPR-type extended signal peptide-containing protein -
FYK42_RS14120 (2874141) 2874141..2875013 - 873 WP_063097554.1 GTPase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgB / csgD / csgE / csgF / csgG / wbbN / glf / wbbM / wzt / wzm 2861928..2910687 48759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-113)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T138246 WP_000854686.1 NZ_CP043284:c2870927-2870544 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T138246 NZ_CP057481:c3571492-3571085 [Escherichia fergusonii]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGCATGGACGAAGCAGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13950.74 Da        Isoelectric Point: 5.0823

>AT138246 WP_001360163.1 NZ_CP043284:c2871384-2871004 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCIVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT138246 NZ_CP057481:c3571739-3571473 [Escherichia fergusonii]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1M0YJ34

References