Detailed information of TA system TA137177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2939534..2940147
• Replicon: chromosome
• Accession: NZ_CP043092
• Organism: Bordetella parapertussis strain J280

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYB29_RS14015
• Protein ID: WP_003811545.1
• Coordinates: 2939534..2939845 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYB29_RS14020
• Protein ID: WP_003811547.1
• Coordinates: 2939848..2940147 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB29_RS13990	2934686..2935240	-	555	Protein_2742	LamB/YcsF family protein	-
FYB29_RS13995	2935237..2936631	-	1395	WP_003811536.1	arylsulfatase	-
FYB29_RS14000	2936646..2937608	-	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB29_RS14005	2937725..2938678	+	954	WP_041937234.1	LysR family transcriptional regulator	-
FYB29_RS14010	2938797..2939420	+	624	WP_003811542.1	glutathione S-transferase family protein	-
FYB29_RS14015	2939534..2939845	+	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYB29_RS14020	2939848..2940147	+	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
FYB29_RS14025	2940161..2942752	-	2592	WP_065956700.1	autotransporter domain-containing protein	-
FYB29_RS14030	2942882..2943556	+	675	WP_010928712.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137177 WP_003811545.1 NZ_CP043092:2939534-2939845 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137177 NZ_CP056559:2352024-2352506 [Citrobacter freundii]
ATGGAAATAAACGTCACGGCGCCGGCGCTGCTGACCGAAGGGCATGATCTACAGCCATTCAATTGCGGTAATGAGGTGTT
AAATGATTGGCTACGTCGCCGGGCGATTAAAAATCAGTACCTCAACGCATCGCGCACATTCGTCATTTGTCTGGAGTCTA
CTCAGCGCGTAGTGGGTTACTATTCCATTGCAACTGGATCTGTAAGCCACGCTGACTTAGGCCGTAGTTTACGTCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTCTGTTGGGCCGTCTTGCTGTTGATGCCAGTACGCAAGGTCATAGTTATGGAAAATG
GCTGCTTAATGATGCTGTACTGCGCATTTCCAACTTAGCCGATCAAGTGGGTATCAAAGCCATCATGGTACATGCTATTG
ATGGCAAGGCCAGAGCGTTCTATGAATATTTTGGTTTCGTTCAGTCCCCAATAGCGGCAAATACGTTGTTCTACAAAATT
TAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137177 WP_003811547.1 NZ_CP043092:2939848-2940147 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137177 NZ_CP043092:2939848-2940147 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3