Detailed information of TA system TA137176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2225686..2226280
• Replicon: chromosome
• Accession: NZ_CP043092
• Organism: Bordetella parapertussis strain J280

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB29_RS10620
• Protein ID: WP_010928352.1
• Coordinates: 2226098..2226280 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB29_RS10615
• Protein ID: WP_010928351.1
• Coordinates: 2225686..2226075 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB29_RS10590	2221529..2222569	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYB29_RS10595	2222704..2223720	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB29_RS10600	2223742..2224599	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB29_RS10605	2224644..2225420	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB29_RS10615	2225686..2226075	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB29_RS10620	2226098..2226280	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB29_RS10625	2226688..2227386	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB29_RS10630	2227390..2229159	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB29_RS10635	2229170..2230525	+	1356	WP_003809657.1	cytochrome c	-
FYB29_RS10640	2230537..2231277	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137176 WP_010928352.1 NZ_CP043092:c2226280-2226098 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137176 NZ_CP056559:c2312264-2311986 [Citrobacter freundii]
ATGATCATGAACTTCAGACACAAAGGATTGCGCGACTTGTTTCTTCAGGGGCGAACATCAGGCGTGACGGCGAAGCATGT
CCGGCGATTGCGGCACCGACTTGCCGTTATTGATGCAGCGAGCCATGTAACAGATATCAATATGCCTGGTTATAAACTGC
ATGCGTTAACGGGCGATCGCGACGGCGTTTGGTCGATTTCTGTTTCAGGCAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGATGCATATATACTGGATTACGAGGACTATCATTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137176 WP_010928351.1 NZ_CP043092:c2226075-2225686 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137176 NZ_CP056559:c2311986-2311702 [Citrobacter freundii]
ATGAAAATGGCTAATCATCCCCGTCCGGGGGATATTATTCAGGAAGCGCTGGATGAGTTAAACGTCAGCCTGCGCGAATT
TGCCAGAGCAATGGAGATTGCCCCCTCAACCGCGAGCCGACTGTTAACGGGCAAGGCAGCATTAACCCCGGAAATGGCGA
TCAAACTTTCAGTGGTGATCGGCAGTTCGCCCGAAATGTGGTTGAATCTGCAGAATGCCTGGAGTCTGGCTGAAGCGCAA
AAAAGCGTGGATATCTCACGTCTGCGCAAACTGGTAGCACAGTAA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7