Detailed information of TA system TA137125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1301589..1302250
• Replicon: chromosome
• Accession: NZ_CP043082
• Organism: Bordetella parapertussis strain J297

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB41_RS06105
• Protein ID: WP_003812073.1
• Coordinates: 1301589..1302014 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB41_RS06110
• Protein ID: WP_003812071.1
• Coordinates: 1302011..1302250 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB41_RS06085	1297403..1298380	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB41_RS06090	1298401..1298913	-	513	WP_010928017.1	hypothetical protein	-
FYB41_RS06095	1299412..1300917	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB41_RS06100	1301015..1301479	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB41_RS06105	1301589..1302014	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB41_RS06110	1302011..1302250	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB41_RS06115	1302324..1303166	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB41_RS06120	1303304..1303849	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYB41_RS06125	1303908..1304420	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYB41_RS06130	1304501..1304734	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB41_RS06135	1304731..1305291	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB41_RS06140	1305369..1306415	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB41_RS06145	1306412..1307215	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137125 WP_003812073.1 NZ_CP043082:c1302014-1301589 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137125 NZ_CP043082:c1302014-1301589 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137125 WP_003812071.1 NZ_CP043082:c1302250-1302011 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137125 NZ_CP043082:c1302250-1302011 [Bordetella parapertussis]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCTCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: Q7WAH5