Detailed information of TA system TA137074

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1728017..1728630
• Replicon: chromosome
• Accession: NZ_CP043071
• Organism: Bordetella parapertussis strain J602

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYB52_RS08110
• Protein ID: WP_003811545.1
• Coordinates: 1728319..1728630 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYB52_RS08105
• Protein ID: WP_003811547.1
• Coordinates: 1728017..1728316 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB52_RS08095	1724608..1725282	-	675	WP_010928712.1	response regulator transcription factor	-
FYB52_RS08100	1725412..1728003	+	2592	WP_065956700.1	autotransporter domain-containing protein	-
FYB52_RS08105	1728017..1728316	-	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
FYB52_RS08110	1728319..1728630	-	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYB52_RS08115	1728744..1729367	-	624	WP_003811542.1	glutathione S-transferase family protein	-
FYB52_RS08120	1729486..1730439	-	954	WP_041937234.1	LysR family transcriptional regulator	-
FYB52_RS08125	1730556..1731518	+	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB52_RS08130	1731533..1732927	+	1395	WP_003811536.1	arylsulfatase	-
FYB52_RS08135	1732924..1733478	+	555	Protein_1602	LamB/YcsF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137074 WP_003811545.1 NZ_CP043071:c1728630-1728319 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137074 NZ_CP056451:c4555313-4554954 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACTTGCTTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCAGGGGTTC
TGGAGGTCGTTGAGGATTACCACGGTAGCGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAATCCGTTTCCGGGAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137074 WP_003811547.1 NZ_CP043071:c1728316-1728017 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137074 NZ_CP043071:c1728316-1728017 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3