Detailed information of TA system TA136959

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 2272832..2273053
• Replicon: chromosome
• Accession: NZ_CP043033
• Organism: Escherichia coli strain XDL

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A229AEQ8
• Locus tag: EOV66_RS10880
• Protein ID: WP_000176713.1
• Coordinates: 2272832..2272939 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	2272987..2273053 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOV66_RS10855	2268676..2269758	+	1083	WP_000804726.1	peptide chain release factor 1	-
EOV66_RS10860	2269758..2270591	+	834	WP_000456446.1	peptide chain release factor N(5)-glutamine methyltransferase	-
EOV66_RS10865	2270588..2270980	+	393	WP_000200374.1	invasion regulator SirB2	-
EOV66_RS10870	2270984..2271793	+	810	WP_001257044.1	invasion regulator SirB1	-
EOV66_RS10875	2271829..2272683	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
EOV66_RS10880	2272832..2272939	-	108	WP_000176713.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2272987..2273053	+	67	NuclAT_11	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_11	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_11	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_11	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_13	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_13	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_13	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_13	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_15	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_15	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_15	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_15	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_17	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_17	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_17	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_17	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_19	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_19	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_19	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_19	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_21	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_21	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_21	-	Antitoxin
-	2272987..2273053	+	67	NuclAT_21	-	Antitoxin
-	2272989..2273052	+	64	NuclAT_49	-	-
-	2272989..2273052	+	64	NuclAT_49	-	-
-	2272989..2273052	+	64	NuclAT_49	-	-
-	2272989..2273052	+	64	NuclAT_49	-	-
-	2272989..2273052	+	64	NuclAT_51	-	-
-	2272989..2273052	+	64	NuclAT_51	-	-
-	2272989..2273052	+	64	NuclAT_51	-	-
-	2272989..2273052	+	64	NuclAT_51	-	-
-	2272989..2273052	+	64	NuclAT_53	-	-
-	2272989..2273052	+	64	NuclAT_53	-	-
-	2272989..2273052	+	64	NuclAT_53	-	-
-	2272989..2273052	+	64	NuclAT_53	-	-
EOV66_RS10890	2273367..2273474	-	108	WP_000170956.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	2273527..2273588	+	62	NuclAT_48	-	-
-	2273527..2273588	+	62	NuclAT_48	-	-
-	2273527..2273588	+	62	NuclAT_48	-	-
-	2273527..2273588	+	62	NuclAT_48	-	-
-	2273527..2273588	+	62	NuclAT_50	-	-
-	2273527..2273588	+	62	NuclAT_50	-	-
-	2273527..2273588	+	62	NuclAT_50	-	-
-	2273527..2273588	+	62	NuclAT_50	-	-
-	2273527..2273588	+	62	NuclAT_52	-	-
-	2273527..2273588	+	62	NuclAT_52	-	-
-	2273527..2273588	+	62	NuclAT_52	-	-
-	2273527..2273588	+	62	NuclAT_52	-	-
-	2273527..2273589	+	63	NuclAT_12	-	-
-	2273527..2273589	+	63	NuclAT_12	-	-
-	2273527..2273589	+	63	NuclAT_12	-	-
-	2273527..2273589	+	63	NuclAT_12	-	-
-	2273527..2273589	+	63	NuclAT_14	-	-
-	2273527..2273589	+	63	NuclAT_14	-	-
-	2273527..2273589	+	63	NuclAT_14	-	-
-	2273527..2273589	+	63	NuclAT_14	-	-
-	2273527..2273589	+	63	NuclAT_16	-	-
-	2273527..2273589	+	63	NuclAT_16	-	-
-	2273527..2273589	+	63	NuclAT_16	-	-
-	2273527..2273589	+	63	NuclAT_16	-	-
-	2273527..2273589	+	63	NuclAT_18	-	-
-	2273527..2273589	+	63	NuclAT_18	-	-
-	2273527..2273589	+	63	NuclAT_18	-	-
-	2273527..2273589	+	63	NuclAT_18	-	-
-	2273527..2273589	+	63	NuclAT_20	-	-
-	2273527..2273589	+	63	NuclAT_20	-	-
-	2273527..2273589	+	63	NuclAT_20	-	-
-	2273527..2273589	+	63	NuclAT_20	-	-
-	2273527..2273589	+	63	NuclAT_22	-	-
-	2273527..2273589	+	63	NuclAT_22	-	-
-	2273527..2273589	+	63	NuclAT_22	-	-
-	2273527..2273589	+	63	NuclAT_22	-	-
EOV66_RS10900	2273880..2274980	-	1101	WP_001317783.1	sodium-potassium/proton antiporter ChaA	-
EOV66_RS10905	2275250..2275480	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
EOV66_RS10910	2275638..2276333	+	696	WP_012311798.1	glutathione-specific gamma-glutamylcyclotransferase	-
EOV66_RS10915	2276377..2276730	-	354	WP_001169669.1	DsrE/F sulfur relay family protein YchN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4031.79 Da
• Isoelectric Point: 11.4779

>T136959 WP_000176713.1 NZ_CP043033:c2272939-2272832 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Nucleotide

• Length: 108 bp

>T136959 NZ_CP056372:c4890480-4889563 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT136959 NZ_CP043033:2272987-2273053 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A229AEQ8

Antitoxin