Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4048635..4049197 Replicon chromosome
Accession NZ_CP043010
Organism Paenarthrobacter ureafaciens strain YL1

Toxin (Protein)


Gene name relE Uniprot ID A0A444GZT3
Locus tag FV140_RS18900 Protein ID WP_052474237.1
Coordinates 4048922..4049197 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7M2BYL4
Locus tag FV140_RS18895 Protein ID WP_021472907.1
Coordinates 4048635..4048910 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV140_RS18875 4044858..4045895 - 1038 WP_031216691.1 zinc-dependent alcohol dehydrogenase family protein -
FV140_RS18880 4046025..4046837 - 813 WP_021472904.1 hypothetical protein -
FV140_RS18885 4046884..4047525 - 642 WP_021472905.1 LysE family translocator -
FV140_RS18890 4047724..4048602 + 879 WP_043427191.1 prephenate dehydratase -
FV140_RS18895 4048635..4048910 + 276 WP_021472907.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FV140_RS18900 4048922..4049197 + 276 WP_052474237.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FV140_RS18905 4049209..4050186 - 978 WP_021472909.1 thioredoxin-disulfide reductase -
FV140_RS18910 4050250..4052421 - 2172 WP_069696782.1 MMPL family transporter -
FV140_RS18915 4052653..4053219 + 567 WP_069696817.1 MarR family transcriptional regulator -
FV140_RS18920 4053300..4054115 + 816 WP_021474094.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10432.02 Da        Isoelectric Point: 10.0347

>T136949 WP_052474237.1 NZ_CP043010:4048922-4049197 [Paenarthrobacter ureafaciens]
MEGEPWNIQVTSPALKTFHRLPEKAASAIVEFITGALAGNPHRLSKPLTNELLGMRTARRGDYRVLFTLDIEDHVLYVHR
IQHRADVYKPR

Download         Length: 276 bp

>T136949 NZ_CP043010:4048922-4049197 [Paenarthrobacter ureafaciens]
TTGGAGGGCGAGCCGTGGAACATTCAGGTCACAAGTCCGGCACTGAAAACATTTCATCGGCTTCCCGAAAAGGCCGCCTC
CGCCATAGTGGAGTTCATAACCGGGGCCCTGGCAGGCAACCCACACCGCCTCAGCAAACCCCTGACCAATGAACTTCTTG
GCATGCGCACCGCCCGCCGAGGTGATTACCGCGTGTTGTTCACCCTCGACATCGAGGACCACGTGCTCTATGTCCATCGA
ATTCAGCACCGCGCAGATGTCTACAAACCTCGCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10112.30 Da        Isoelectric Point: 4.6847

>AT136949 WP_021472907.1 NZ_CP043010:4048635-4048910 [Paenarthrobacter ureafaciens]
MKTVPLSEAKDKLSALVEEADTTHEIIQITRHGHPSAVLMSADDLESLQETIHWLSQPGLREDLAQARRDIAEGNTVSGD
DLRREFGLPPR

Download         Length: 276 bp

>AT136949 NZ_CP043010:4048635-4048910 [Paenarthrobacter ureafaciens]
ATGAAGACGGTTCCCCTCAGCGAGGCCAAGGACAAACTCTCGGCCTTGGTCGAAGAAGCAGACACCACACACGAAATCAT
TCAGATCACTCGCCACGGACACCCGTCGGCCGTCCTCATGTCTGCGGATGACCTGGAATCACTTCAGGAAACCATCCACT
GGCTGTCCCAACCGGGCCTACGTGAGGATCTTGCACAGGCTCGCCGCGATATCGCAGAGGGCAACACAGTAAGCGGCGAT
GACCTGCGCCGTGAATTCGGACTGCCTCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444GZT3

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2BYL4

References