Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1013875..1014433 Replicon chromosome
Accession NZ_CP042993
Organism Histophilus somni strain UOC-KLM-ATR-014

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FWK62_RS05040 Protein ID WP_147590366.1
Coordinates 1013875..1014147 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FWK62_RS05045 Protein ID WP_132994429.1
Coordinates 1014140..1014433 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK62_RS05000 1009013..1009297 + 285 WP_075321052.1 integration host factor subunit beta -
FWK62_RS05005 1009417..1009701 + 285 WP_012340596.1 DUF1049 domain-containing protein -
FWK62_RS05010 1009711..1010907 + 1197 WP_075293930.1 lipopolysaccharide assembly protein LapB -
FWK62_RS05015 1010931..1011437 - 507 WP_075293929.1 GNAT family N-acetyltransferase -
FWK62_RS05020 1011427..1011726 - 300 WP_012340592.1 DUF1778 domain-containing protein -
FWK62_RS05025 1011925..1012206 - 282 WP_132994427.1 virulence factor -
FWK62_RS05030 1012647..1013207 + 561 WP_147590364.1 porin -
FWK62_RS05035 1013227..1013790 + 564 WP_187378125.1 porin -
FWK62_RS05040 1013875..1014147 - 273 WP_147590366.1 type II toxin-antitoxin system YafQ family toxin Toxin
FWK62_RS05045 1014140..1014433 - 294 WP_132994429.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FWK62_RS05050 1014892..1015272 - 381 WP_075293926.1 SufE family protein -
FWK62_RS05055 1015269..1016468 - 1200 WP_132994432.1 cysteine desulfurase -
FWK62_RS05060 1016458..1016961 - 504 WP_041604213.1 thermonuclease family protein -
FWK62_RS05065 1017087..1017503 + 417 WP_075293924.1 CidA/LrgA family protein -
FWK62_RS05070 1017500..1018189 + 690 WP_075293923.1 CidB/LrgB family autolysis modulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(15-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-59)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10286.96 Da        Isoelectric Point: 6.6267

>T136887 WP_147590366.1 NZ_CP042993:c1014147-1013875 [Histophilus somni]
MAKRNCGVTLPCKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIKEMVEVVVELH
YLDSHSEIFG

Download         Length: 273 bp

>T136887 NZ_CP042993:c1014147-1013875 [Histophilus somni]
ATGGCTAAACGTAATTGTGGAGTTACATTACCTTGTAAACGTGATTTGAGAAAACATTACTTGGCTTTAGTCGGCGAAGC
ATGGGCAGAGATTTCAAACTGTCTTTTGAATGACTTGCCAATTCCTGAAAAGTATCAAGATCACCCGCTTAAAGGCGATA
AATCAGGCTTTCGAGACTGCCATGTCAAACCGGATTTAGTGTTGATAAAGGAGATGGTTGAGGTTGTTGTGGAGTTACAT
TACCTTGATAGCCATAGCGAAATTTTTGGCTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11329.67 Da        Isoelectric Point: 5.1053

>AT136887 WP_132994429.1 NZ_CP042993:c1014433-1014140 [Histophilus somni]
MDYTNFNMRLDNDLRRRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FNSLDELNQAIKEISHG

Download         Length: 294 bp

>AT136887 NZ_CP056298:c61035-60769 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References