Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 461068..461705 Replicon chromosome
Accession NZ_CP042993
Organism Histophilus somni strain UOC-KLM-ATR-014

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FWK62_RS02370 Protein ID WP_011609928.1
Coordinates 461068..461304 (+) Length 79 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag FWK62_RS02375 Protein ID WP_011609927.1
Coordinates 461442..461705 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FWK62_RS02345 456122..456541 + 420 WP_178384271.1 hypothetical protein -
FWK62_RS02350 456543..456905 + 363 WP_135026582.1 hypothetical protein -
FWK62_RS02355 456982..459255 + 2274 WP_132995746.1 hypothetical protein -
FWK62_RS10290 459926..460615 + 690 WP_187378113.1 hypothetical protein -
FWK62_RS02365 460736..460992 + 257 Protein_457 DUF1778 domain-containing protein -
FWK62_RS02370 461068..461304 + 237 WP_011609928.1 hypothetical protein Toxin
FWK62_RS02375 461442..461705 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
FWK62_RS02380 461707..462174 + 468 WP_011609926.1 GNAT family N-acetyltransferase -
FWK62_RS02390 462853..463155 - 303 WP_147590287.1 DUF2442 domain-containing protein -
FWK62_RS02395 463124..463378 - 255 WP_075294104.1 DUF4160 domain-containing protein -
FWK62_RS02400 463510..463770 - 261 Protein_463 hemophilus-specific protein -
FWK62_RS02405 463846..464262 - 417 WP_075319814.1 IS200/IS605 family transposase -
FWK62_RS02410 464309..465445 + 1137 WP_075319813.1 transposase -
FWK62_RS02415 465701..466645 + 945 WP_147590288.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 463846..464262 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 8873.59 Da        Isoelectric Point: 10.4575

>T136885 WP_011609928.1 NZ_CP042993:461068-461304 [Histophilus somni]
MNLYLQKQVSQDIKRRIAPCFTVIDENKRILGYYTLASTSIPLVSLPENLKKKLPRYPSVPAVLLGRLAVDKQVSIFI

Download         Length: 237 bp

>T136885 NZ_CP042993:461068-461304 [Histophilus somni]
TTGAATCTCTATTTACAAAAACAGGTTTCACAAGATATCAAAAGGCGTATTGCTCCTTGCTTTACTGTCATTGATGAAAA
TAAACGTATTTTAGGCTACTATACTTTAGCCTCAACAAGCATTCCTCTTGTCTCTCTCCCTGAGAACCTTAAGAAAAAAT
TACCCCGTTATCCTAGTGTTCCGGCGGTTTTACTTGGACGCTTAGCCGTTGACAAGCAAGTCTCAATATTCATTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT136885 WP_011609927.1 NZ_CP042993:461442-461705 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT136885 NZ_CP042993:461442-461705 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References