136827

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4573265..4573781 Replicon chromosome
Accession NZ_CP042977
Organism Klebsiella pneumoniae strain KPN55602

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FVE92_RS24240 Protein ID WP_004178374.1
Coordinates 4573265..4573549 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FVE92_RS24245 Protein ID WP_002886901.1
Coordinates 4573539..4573781 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE92_RS24215 4568748..4569056 - 309 WP_004210629.1 PTS sugar transporter subunit IIB -
FVE92_RS24220 4569141..4569314 + 174 WP_004210630.1 hypothetical protein -
FVE92_RS24225 4569317..4570060 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FVE92_RS24230 4570417..4572555 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FVE92_RS24235 4572797..4573261 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FVE92_RS24240 4573265..4573549 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVE92_RS24245 4573539..4573781 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FVE92_RS24250 4573859..4575769 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FVE92_RS24255 4575792..4576946 - 1155 WP_004210635.1 lactonase family protein -
FVE92_RS24260 4577013..4577753 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T136827 WP_004178374.1 NZ_CP042977:c4573549-4573265 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T136827 NZ_CP042977:c4573549-4573265 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT136827 WP_002886901.1 NZ_CP042977:c4573781-4573539 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT136827 NZ_CP056245:c4776521-4776279 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGGCAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References