Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3878964..3879583 Replicon chromosome
Accession NZ_CP042946
Organism Escherichia fergusonii strain ATCC 35470

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag ABH49_RS18690 Protein ID WP_001280991.1
Coordinates 3878964..3879182 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag ABH49_RS18695 Protein ID WP_000344803.1
Coordinates 3879209..3879583 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH49_RS18660 3874621..3875193 + 573 WP_105283955.1 YbaY family lipoprotein -
ABH49_RS18665 3875224..3875535 - 312 WP_000409911.1 MGMT family protein -
ABH49_RS18675 3875914..3876267 + 354 WP_000878140.1 DUF1428 domain-containing protein -
ABH49_RS18680 3876309..3877859 - 1551 WP_046080588.1 EAL domain-containing protein -
ABH49_RS18685 3877998..3878467 - 470 Protein_3603 YlaC family protein -
ABH49_RS18690 3878964..3879182 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
ABH49_RS18695 3879209..3879583 - 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
ABH49_RS18700 3880086..3883235 - 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
ABH49_RS18705 3883258..3884451 - 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T136730 WP_001280991.1 NZ_CP042946:c3879182-3878964 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T136730 NZ_CP042946:c3879182-3878964 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT136730 WP_000344803.1 NZ_CP042946:c3879583-3879209 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT136730 NZ_CP042946:c3879583-3879209 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTATTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References