Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 604933..605404 | Replicon | chromosome |
| Accession | NZ_CP042892 | ||
| Organism | Escherichia coli O10:H32 strain NMBU-W12E19 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | FVP48_RS05505 | Protein ID | WP_001303511.1 |
| Coordinates | 605126..605404 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | FVP48_RS05500 | Protein ID | WP_001302048.1 |
| Coordinates | 604933..605124 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FVP48_RS05455 | 600030..600491 | - | 462 | WP_001209473.1 | ead/Ea22-like family protein | - |
| FVP48_RS05460 | 600488..600784 | - | 297 | WP_001266130.1 | DUF4406 domain-containing protein | - |
| FVP48_RS05465 | 600781..601173 | - | 393 | WP_001792328.1 | DUF977 family protein | - |
| FVP48_RS05470 | 601189..601959 | - | 771 | WP_112912496.1 | DUF1627 domain-containing protein | - |
| FVP48_RS05475 | 601981..602727 | - | 747 | WP_000788950.1 | ATP-binding protein | - |
| FVP48_RS05480 | 602734..603696 | - | 963 | WP_016234248.1 | helix-turn-helix domain-containing protein | - |
| FVP48_RS05485 | 603719..604144 | - | 426 | WP_032210757.1 | Rha family transcriptional regulator | - |
| FVP48_RS05490 | 604141..604443 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| FVP48_RS05495 | 604541..604912 | + | 372 | WP_123007420.1 | hypothetical protein | - |
| FVP48_RS05500 | 604933..605124 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| FVP48_RS05505 | 605126..605404 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FVP48_RS05510 | 605696..605851 | + | 156 | WP_000379589.1 | DUF1391 family protein | - |
| FVP48_RS05515 | 606011..606229 | + | 219 | WP_001171951.1 | hypothetical protein | - |
| FVP48_RS05520 | 606252..606653 | + | 402 | WP_000394529.1 | hypothetical protein | - |
| FVP48_RS05525 | 606613..606891 | - | 279 | WP_000358771.1 | hypothetical protein | - |
| FVP48_RS05530 | 607451..607639 | + | 189 | WP_000449172.1 | cell division inhibitor | - |
| FVP48_RS05535 | 607636..607824 | + | 189 | WP_000199480.1 | DUF1482 family protein | - |
| FVP48_RS05540 | 607919..610390 | + | 2472 | WP_173002262.1 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 557508..618976 | 61468 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T136436 WP_001303511.1 NZ_CP042892:605126-605404 [Escherichia coli O10:H32]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T136436 NZ_CP042892:605126-605404 [Escherichia coli O10:H32]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAG
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAG
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT136436 WP_001302048.1 NZ_CP042892:604933-605124 [Escherichia coli O10:H32]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT136436 NZ_CP042892:604933-605124 [Escherichia coli O10:H32]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|