Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1809716..1810547 Replicon chromosome
Accession NZ_CP042867
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag BAA196FS_RS08625 Protein ID WP_000854814.1
Coordinates 1809716..1810090 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag BAA196FS_RS08630 Protein ID WP_001285584.1
Coordinates 1810179..1810547 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196FS_RS08585 1805112..1806278 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
BAA196FS_RS08590 1806397..1806870 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
BAA196FS_RS08595 1807068..1808126 + 1059 WP_001200891.1 FUSC family protein -
BAA196FS_RS08600 1808298..1808627 + 330 WP_000450409.1 DUF496 family protein -
BAA196FS_RS08605 1808728..1808910 - 183 WP_001016348.1 hypothetical protein -
BAA196FS_RS08610 1808982..1809110 + 129 Protein_1675 transposase domain-containing protein -
BAA196FS_RS08615 1809399..1809512 - 114 WP_001161660.1 DUF957 domain-containing protein -
BAA196FS_RS08620 1809525..1809719 - 195 WP_000988600.1 hypothetical protein -
BAA196FS_RS08625 1809716..1810090 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
BAA196FS_RS08630 1810179..1810547 - 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BAA196FS_RS08635 1810621..1810842 - 222 WP_000692323.1 DUF987 domain-containing protein -
BAA196FS_RS08640 1810905..1811351 - 447 WP_000187523.1 RadC family protein -
BAA196FS_RS08645 1811348..1812880 - 1533 WP_001350525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T136329 WP_000854814.1 NZ_CP042867:c1810090-1809716 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T136329 NZ_CP042867:c1810090-1809716 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT136329 WP_001285584.1 NZ_CP042867:c1810547-1810179 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT136329 NZ_CP055509:c4745248-4744982 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References