Detailed information of TA system TA136281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2984289..2984824
• Replicon: chromosome
• Accession: NZ_CP042861
• Organism: Providencia sp. 1709051003

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: FVA72_RS13635
• Protein ID: WP_110591513.1
• Coordinates: 2984516..2984824 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: D4BV21
• Locus tag: FVA72_RS13630
• Protein ID: WP_004255691.1
• Coordinates: 2984289..2984516 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVA72_RS13615	2979658..2980629	+	972	WP_110591515.1	Abi family protein	-
FVA72_RS13620	2980782..2982881	-	2100	WP_004255687.1	flagellar biosynthesis protein FlhA	-
FVA72_RS13625	2982874..2984025	-	1152	WP_110591514.1	flagellar type III secretion system protein FlhB	-
FVA72_RS13630	2984289..2984516	+	228	WP_004255691.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
FVA72_RS13635	2984516..2984824	+	309	WP_110591513.1	CcdB family protein	Toxin
FVA72_RS13640	2984840..2985397	+	558	WP_110591512.1	hypothetical protein	-
FVA72_RS13645	2985440..2985673	-	234	WP_080544466.1	helix-turn-helix domain-containing protein	-
FVA72_RS13650	2985844..2986482	-	639	WP_094961165.1	protein phosphatase CheZ	-
FVA72_RS13655	2986507..2986899	-	393	WP_004255705.1	chemotaxis response regulator CheY	-
FVA72_RS13660	2986941..2988008	-	1068	WP_110591511.1	chemotaxis response regulator protein-glutamate methylesterase	-
FVA72_RS13665	2988008..2988844	-	837	WP_004255713.1	chemotaxis protein-glutamate O-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (5-75)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11786.87 Da
• Isoelectric Point: 8.0469

>T136281 WP_110591513.1 NZ_CP042861:2984516-2984824 [Providencia sp. 1709051003]
MQYRLYQNRDDAIKYPYLLDIQSNIIDLLNTRLVIPLFDSRLVKKPLPVRLNPQLSINGQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Nucleotide

• Length: 309 bp

>T136281 NZ_CP042861:2984516-2984824 [Providencia sp. 1709051003]
ATGCAATATCGCCTCTATCAAAACCGAGATGATGCTATCAAATACCCATATTTACTGGATATTCAAAGTAATATTATTGA
TTTATTGAATACTCGCTTAGTCATCCCGTTATTCGATAGCAGGCTAGTTAAAAAGCCATTACCTGTACGCTTAAATCCAC
AATTATCAATCAACGGGCAGGTTTTTATTTTAATGACTCACCAAATGGCTTGCGTCCCTCATTCATTATTAGGGAAAGAA
ATCGTTGACTTAAGTAGCCAACGAGACACCATTAAACACGCAATTGACTTACTGATTGATGGCTTTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8688.92 Da
• Isoelectric Point: 8.9375

>AT136281 WP_004255691.1 NZ_CP042861:2984289-2984516 [Providencia sp. 1709051003]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Nucleotide

• Length: 228 bp

>AT136281 NZ_CP042861:2984289-2984516 [Providencia sp. 1709051003]
ATGAATAGAACAAAAAAAACCGTCAGTGTTACTGTCGCGCCTGAACTCTACGAACAAGCAAGGCGGGCTAAACTTAACTT
ATCAGCAATACTGGCTTGTGCCTTACAAGCTGAATTAAAACGCCTCGAAGCGCAAAAATGGAAAAATGACAATGTCGAAG
GCTTTAATGAGTTAAACAGGATAAATGAAGAATATGGATTACTCTCAGATAAATACAAGGATTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G6Q922