Detailed information of TA system TA136006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 418966..419486
• Replicon: chromosome
• Accession: NZ_CP042650
• Organism: Staphylococcus aureus strain X22

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: FTD94_RS02070
• Protein ID: WP_044292249.1
• Coordinates: 419178..419486 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: A0A2X2M557
• Locus tag: FTD94_RS02065
• Protein ID: WP_001058488.1
• Coordinates: 418966..419175 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTD94_RS02025	413996..414238	+	243	WP_000897044.1	30S ribosomal protein S18	-
FTD94_RS02030	414467..415264	-	798	WP_000119675.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FTD94_RS02035	415288..416502	-	1215	WP_044292239.1	site-specific integrase	-
FTD94_RS02040	416506..417318	-	813	WP_115208073.1	hypothetical protein	-
FTD94_RS02045	417426..418145	-	720	WP_052502250.1	helix-turn-helix domain-containing protein	-
FTD94_RS02050	418331..418543	+	213	WP_044292240.1	helix-turn-helix transcriptional regulator	-
FTD94_RS02055	418544..418815	+	272	Protein_400	winged helix-turn-helix domain-containing protein	-
FTD94_RS02060	418827..418973	+	147	WP_000784888.1	hypothetical protein	-
FTD94_RS02065	418966..419175	+	210	WP_001058488.1	hypothetical protein	Antitoxin
FTD94_RS02070	419178..419486	+	309	WP_044292249.1	DUF1474 family protein	Toxin
FTD94_RS02075	419546..421162	+	1617	WP_044292251.1	hypothetical protein	-
FTD94_RS02080	421338..422141	+	804	WP_044292253.1	bifunctional DNA primase/polymerase	-
FTD94_RS02085	422128..422427	+	300	WP_078103647.1	pathogenicity island protein	-
FTD94_RS02090	422402..423043	+	642	WP_044292258.1	pathogenicity island protein	-
FTD94_RS02095	423560..423916	+	357	WP_044292260.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	413441..426078	12637

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-97)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 12011.48 Da
• Isoelectric Point: 4.5059

>T136006 WP_044292249.1 NZ_CP042650:419178-419486 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFTQETFLTNELGTKQEHISYSVGYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASLSTDQSESNANVQSI

Nucleotide

• Length: 309 bp

>T136006 NZ_CP042650:419178-419486 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACACGG
TTGGTTTACTCAGGAGACGTTTCTAACAAATGAATTAGGAACAAAACAAGAGCATATCAGTTACTCAGTGGGTTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CACGAAATAGAAAAAGCGTCACTCTCCACCGACCAAAGCGAAAGTAACGCAAATGTGCAAAGTATTTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8287.31 Da
• Isoelectric Point: 4.2820

>AT136006 WP_001058488.1 NZ_CP042650:418966-419175 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT136006 NZ_CP042650:418966-419175 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2X2M557