Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4192976..4193553 Replicon chromosome
Accession NZ_CP042596
Organism Granulicella sp. WH15

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FTO74_RS17385 Protein ID WP_162539279.1
Coordinates 4193272..4193553 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FTO74_RS17380 Protein ID WP_162539278.1
Coordinates 4192976..4193260 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO74_RS17360 4188106..4188558 - 453 WP_162539274.1 hypothetical protein -
FTO74_RS17365 4188568..4190790 - 2223 WP_162539275.1 oligopeptide transporter, OPT family -
FTO74_RS17370 4191566..4192279 + 714 WP_174242275.1 ComF family protein -
FTO74_RS17375 4192283..4192960 + 678 WP_162539277.1 HNH endonuclease -
FTO74_RS17380 4192976..4193260 - 285 WP_162539278.1 HigA family addiction module antidote protein Antitoxin
FTO74_RS17385 4193272..4193553 - 282 WP_162539279.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FTO74_RS17390 4193621..4194268 - 648 WP_162539280.1 hypothetical protein -
FTO74_RS17395 4194456..4194719 + 264 WP_162539281.1 hypothetical protein -
FTO74_RS17400 4194859..4195635 - 777 WP_162539969.1 outer membrane lipoprotein-sorting protein -
FTO74_RS17405 4195902..4197413 + 1512 WP_162539282.1 HAMP domain-containing histidine kinase -
FTO74_RS19410 4197467..4197787 - 321 WP_174242238.1 hypothetical protein -
FTO74_RS17415 4197786..4198340 + 555 WP_162539284.1 recombination regulator RecX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10858.46 Da        Isoelectric Point: 10.3718

>T136002 WP_162539279.1 NZ_CP042596:c4193553-4193272 [Granulicella sp. WH15]
MILGFRDADTELLWKTGKSRRVPASIRRTAWKKLAILNAAIELDNLKIPPGNRLEALTKDRRGQHSIRVNDQYRVCFRWF
DGNAHDVEIVDYH

Download         Length: 282 bp

>T136002 NZ_CP042596:c4193553-4193272 [Granulicella sp. WH15]
ATGATCCTGGGCTTCCGCGATGCGGATACAGAGCTGCTTTGGAAGACGGGGAAGAGCCGTCGCGTTCCAGCCAGCATCCG
CCGCACGGCCTGGAAGAAGCTGGCGATCTTGAATGCGGCTATTGAGCTGGACAACCTGAAGATCCCGCCGGGTAATCGTC
TTGAGGCCCTGACGAAAGATCGCAGGGGGCAGCATAGTATCCGCGTCAACGATCAATATCGGGTCTGTTTTCGCTGGTTC
GACGGCAACGCTCACGATGTGGAGATCGTGGATTACCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10548.22 Da        Isoelectric Point: 7.3176

>AT136002 WP_162539278.1 NZ_CP042596:c4193260-4192976 [Granulicella sp. WH15]
MAKVFAIHPGEILLTEFMEPLGLSSYRLAKELGVPLPRVNDIVHGKRSISADTALRFGIFFGLPAQFWLNLQNDYDLRLA
NTDDLSKIRPHQAA

Download         Length: 285 bp

>AT136002 NZ_CP042596:c4193260-4192976 [Granulicella sp. WH15]
ATGGCCAAAGTTTTTGCGATTCATCCCGGCGAGATTCTGCTTACGGAGTTCATGGAGCCGCTGGGGCTAAGTTCTTACCG
GCTCGCCAAGGAGTTGGGCGTTCCGCTACCCCGTGTGAATGACATCGTACATGGCAAGCGCTCCATCTCGGCCGATACGG
CGCTCCGCTTCGGTATCTTCTTCGGCTTGCCTGCGCAGTTCTGGCTCAACCTGCAGAACGATTACGACCTGCGACTTGCC
AACACGGATGACTTGTCCAAGATCAGGCCGCATCAGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References