Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3535134..3535714 Replicon chromosome
Accession NZ_CP042596
Organism Granulicella sp. WH15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FTO74_RS14695 Protein ID WP_162538821.1
Coordinates 3535134..3535505 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FTO74_RS14700 Protein ID WP_162538822.1
Coordinates 3535499..3535714 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO74_RS14675 3530454..3532775 - 2322 WP_162539911.1 transpeptidase family protein -
FTO74_RS14680 3532809..3533321 - 513 WP_162538818.1 cell division protein FtsL -
FTO74_RS14685 3533325..3534284 - 960 WP_162538819.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
FTO74_RS14690 3534330..3534770 - 441 WP_162538820.1 division/cell wall cluster transcriptional repressor MraZ -
FTO74_RS14695 3535134..3535505 - 372 WP_162538821.1 type II toxin-antitoxin system VapC family toxin Toxin
FTO74_RS14700 3535499..3535714 - 216 WP_162538822.1 ribbon-helix-helix domain-containing protein Antitoxin
FTO74_RS14705 3535762..3536277 - 516 WP_162538823.1 DUF2127 domain-containing protein -
FTO74_RS14710 3536464..3537150 - 687 WP_162538824.1 Fe2+-dependent dioxygenase -
FTO74_RS14715 3537167..3539812 - 2646 WP_162538825.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-108)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13968.24 Da        Isoelectric Point: 6.7271

>T136000 WP_162538821.1 NZ_CP042596:c3535505-3535134 [Granulicella sp. WH15]
MVGTSALFDTNILIDYLSGIEAARVEMDRYQSRAISIITWMEVMAGVKSEHEAETRVFLASFTILPITMATAERAIVMRR
QPRMKLPNAMILASAELSDHLLITRNTRDFSTENPHVRIPYQL

Download         Length: 372 bp

>T136000 NZ_CP042596:c3535505-3535134 [Granulicella sp. WH15]
ATGGTAGGCACCAGCGCCCTTTTCGATACCAACATCCTGATCGACTACCTGAGCGGCATAGAGGCCGCCCGCGTCGAGAT
GGACCGATACCAGAGCCGAGCCATCAGCATCATCACCTGGATGGAGGTGATGGCGGGAGTAAAGTCCGAGCACGAAGCTG
AAACCCGCGTCTTTCTTGCCTCTTTCACGATACTGCCCATCACGATGGCGACCGCTGAGCGTGCCATCGTGATGCGCCGC
CAGCCGCGGATGAAGCTGCCCAACGCCATGATCCTGGCGTCCGCCGAGTTGAGCGACCACCTGCTCATCACTCGCAACAC
GCGGGATTTTTCCACCGAAAACCCTCACGTACGTATCCCCTACCAGCTTTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8212.29 Da        Isoelectric Point: 5.0623

>AT136000 WP_162538822.1 NZ_CP042596:c3535714-3535499 [Granulicella sp. WH15]
MRTLVDIPEDDLNLLNQLSKAGDVPRAELVRQAIAHYLEPHRLAKKSSAFGLWADQPEDGLEFQKRLRDEW

Download         Length: 216 bp

>AT136000 NZ_CP042596:c3535714-3535499 [Granulicella sp. WH15]
ATGCGAACCCTCGTCGATATCCCCGAAGATGACCTGAACCTGCTCAACCAGTTGAGCAAGGCTGGCGATGTTCCGCGCGC
CGAGCTGGTCCGGCAGGCTATCGCCCACTATCTGGAGCCGCACCGTCTGGCAAAGAAGTCCAGCGCCTTCGGCCTGTGGG
CCGACCAGCCGGAGGACGGCCTGGAGTTCCAGAAGCGGCTGCGCGACGAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References