Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 4405656..4406362 Replicon chromosome
Accession NZ_CP042582
Organism Hypericibacter adhaerens strain R5959

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag FRZ61_RS19750 Protein ID WP_151119344.1
Coordinates 4405985..4406362 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag FRZ61_RS19745 Protein ID WP_151119343.1
Coordinates 4405656..4405988 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRZ61_RS19725 4400822..4401637 + 816 WP_151119339.1 inositol monophosphatase -
FRZ61_RS19730 4401882..4403180 + 1299 WP_151119340.1 OmpA family protein -
FRZ61_RS19735 4403270..4404409 + 1140 WP_151119341.1 flagellar motor protein MotA -
FRZ61_RS19740 4404417..4405580 + 1164 WP_151119342.1 peptidoglycan -binding protein -
FRZ61_RS19745 4405656..4405988 - 333 WP_151119343.1 helix-turn-helix domain-containing protein Antitoxin
FRZ61_RS19750 4405985..4406362 - 378 WP_151119344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FRZ61_RS19755 4406464..4408287 - 1824 WP_151119345.1 ATP-binding cassette domain-containing protein -
FRZ61_RS19760 4408315..4408641 - 327 WP_151119346.1 iron donor protein CyaY -
FRZ61_RS19765 4408880..4409104 + 225 WP_151119347.1 50S ribosomal protein L31 -
FRZ61_RS19770 4409190..4409627 - 438 WP_151119348.1 DUF1465 family protein -
FRZ61_RS19775 4409982..4410446 + 465 WP_151119349.1 Hsp20 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14045.95 Da        Isoelectric Point: 9.9912

>T135947 WP_151119344.1 NZ_CP042582:c4406362-4405985 [Hypericibacter adhaerens]
MEDGPARPLEWVGSSRDDLRGFPDDVQDHIGFALYQAQLGSKHRDAKPLTGLGSGILEVVSDFDANSYRAVYLVRFRDAV
YVLHAFQKKSKRGIATPKAEIDLVKRRLKAAEQHYQATYGKGLKR

Download         Length: 378 bp

>T135947 NZ_CP042582:c4406362-4405985 [Hypericibacter adhaerens]
ATGGAAGACGGACCGGCACGGCCTTTGGAATGGGTCGGGTCGAGCAGGGACGATTTAAGAGGGTTTCCTGACGACGTTCA
GGATCATATCGGCTTTGCCCTCTATCAAGCGCAACTCGGATCGAAACACCGCGATGCCAAGCCGCTGACGGGCCTTGGTT
CGGGCATCTTGGAAGTCGTATCGGACTTCGATGCGAACAGCTATCGGGCCGTTTACCTGGTCAGGTTCCGTGATGCGGTT
TATGTGCTTCATGCCTTCCAGAAGAAGTCAAAGCGAGGCATCGCTACACCAAAGGCCGAGATCGACCTGGTGAAGCGAAG
GCTCAAGGCGGCGGAACAGCACTACCAAGCGACTTACGGAAAGGGTTTGAAGCGATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12498.49 Da        Isoelectric Point: 11.8195

>AT135947 WP_151119343.1 NZ_CP042582:c4405988-4405656 [Hypericibacter adhaerens]
MSGKGDTRIERSSGNVFADLGRPDPDLHLLKAGLVSRIDQIIRERRLTQVRVAEILGISQPDVSRLLRGNFRDYSVERLL
RLLTSLGRDVEIVIRKPRARRQGRLSIEAI

Download         Length: 333 bp

>AT135947 NZ_CP055194:3547810-3548184 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References