Detailed information of TA system TA135710

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 398539..399292
• Replicon: chromosome
• Accession: NZ_CP042488
• Organism: Enterobacter hormaechei strain C15

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: R8WN26
• Locus tag: FR808_RS01915
• Protein ID: WP_016154457.1
• Coordinates: 398539..398916 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FR808_RS01920
• Protein ID: WP_162838704.1
• Coordinates: 398966..399292 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR808_RS01890	395918..396538	-	621	WP_032608268.1	DUF2238 domain-containing protein	-
FR808_RS01895	396644..396880	-	237	WP_016154458.1	hypothetical protein	-
FR808_RS01900	396892..397737	-	846	Protein_360	DUF4942 domain-containing protein	-
FR808_RS01905	397818..398021	-	204	WP_009652505.1	DUF957 domain-containing protein	-
FR808_RS01910	398051..398542	-	492	WP_009652438.1	hypothetical protein	-
FR808_RS01915	398539..398916	-	378	WP_016154457.1	TA system toxin CbtA family protein	Toxin
FR808_RS01920	398966..399292	-	327	WP_162838704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FR808_RS01925	399349..399570	-	222	WP_009652392.1	DUF987 domain-containing protein	-
FR808_RS01930	399584..400066	-	483	WP_016154455.1	DNA repair protein RadC	-
FR808_RS01935	400078..400296	-	219	WP_009652503.1	hypothetical protein	-
FR808_RS01940	400307..400768	-	462	WP_045890390.1	antirestriction protein	-
FR808_RS01945	400797..401051	-	255	WP_009652519.1	hypothetical protein	-
FR808_RS01950	401051..401869	-	819	WP_009652424.1	DUF945 domain-containing protein	-
FR808_RS01955	401973..402206	-	234	WP_009652474.1	DUF905 domain-containing protein	-
FR808_RS01960	402262..402483	-	222	WP_009652443.1	hypothetical protein	-
FR808_RS01965	402566..403078	-	513	WP_009652395.1	DUF4234 domain-containing protein	-
FR808_RS01970	403127..403597	-	471	WP_009652431.1	hypothetical protein	-
FR808_RS01975	403644..403955	-	312	WP_009652410.1	hypothetical protein	-
FR808_RS01980	403968..404234	-	267	WP_009652486.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14168.19 Da
• Isoelectric Point: 9.5224

>T135710 WP_016154457.1 NZ_CP042488:c398916-398539 [Enterobacter hormaechei]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T135710 NZ_CP042488:c398916-398539 [Enterobacter hormaechei]
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12079.85 Da
• Isoelectric Point: 6.6283

>AT135710 WP_162838704.1 NZ_CP042488:c399292-398966 [Enterobacter hormaechei]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Nucleotide

• Length: 327 bp

>AT135710 NZ_CP042488:c399292-398966 [Enterobacter hormaechei]
ATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTTTGGCGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACGCGGATTTACGCCATCTCGACCAGGCATTCCCGC
TACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAATCCCCGTCATCAGCACTGCGTCACGCTGTATGCA
AAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGTCTATCTCGCAATTTACCCGACACCTGCAACAAC
AGAATAA

Structures

Toxin

• AlphaFold DB: R8WN26