Detailed information of TA system TA135642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2203108..2203751
• Replicon: chromosome
• Accession: NZ_CP042382
• Organism: Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FGL86_RS10540
• Protein ID: WP_147184520.1
• Coordinates: 2203569..2203751 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FGL86_RS10535
• Protein ID: WP_147184519.1
• Coordinates: 2203108..2203521 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGL86_RS10500	2198758..2199594	+	837	WP_147184515.1	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	-
FGL86_RS10505	2199641..2200201	+	561	WP_147184516.1	NAD(P)H nitroreductase	-
FGL86_RS10510	2200218..2200733	+	516	WP_147184517.1	YiiD C-terminal domain-containing protein	-
FGL86_RS10520	2200928..2201431	-	504	Protein_2037	hypothetical protein	-
FGL86_RS10525	2201471..2201770	+	300	WP_186764379.1	transcriptional regulator	-
FGL86_RS10530	2201854..2203074	+	1221	WP_147184518.1	hypothetical protein	-
FGL86_RS10535	2203108..2203521	-	414	WP_147184519.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FGL86_RS10540	2203569..2203751	-	183	WP_147184520.1	type II toxin-antitoxin system HicA family toxin	Toxin
FGL86_RS10545	2203942..2204201	+	260	Protein_2042	type II toxin-antitoxin system RelE/ParE family toxin	-
FGL86_RS10550	2204203..2204526	+	324	WP_147184521.1	transcriptional regulator	-
FGL86_RS10555	2204826..2205167	-	342	WP_147184522.1	type II toxin-antitoxin system HicB family antitoxin	-
FGL86_RS10560	2205193..2205486	-	294	WP_147184523.1	helix-turn-helix domain-containing protein	-
FGL86_RS10565	2205561..2205887	-	327	WP_147184524.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FGL86_RS10570	2206055..2206474	-	420	WP_147184525.1	hypothetical protein	-
FGL86_RS10575	2206477..2206758	-	282	WP_147184526.1	hypothetical protein	-
FGL86_RS17930	2206806..2206961	+	156	WP_186764529.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2196996..2206758	9762

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6696.77 Da
• Isoelectric Point: 10.9610

>T135642 WP_147184520.1 NZ_CP042382:c2203751-2203569 [Pistricoccus aurantiacus]
VKSSDLIKELEADGWSLDRIKGSHHHFRHPHKPGSVTVPHPKKDLKTGLVKGIRKQAGLK

Nucleotide

• Length: 183 bp

>T135642 NZ_CP042382:c2203751-2203569 [Pistricoccus aurantiacus]
GTGAAAAGCAGCGATCTGATCAAGGAACTCGAAGCGGATGGATGGTCACTCGACAGAATCAAGGGCAGCCATCACCACTT
CAGACACCCCCACAAGCCCGGCTCCGTCACGGTGCCTCATCCCAAGAAGGATCTGAAAACGGGCTTGGTAAAAGGCATCA
GAAAGCAAGCCGGTCTCAAGTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15018.76 Da
• Isoelectric Point: 4.5418

>AT135642 WP_147184519.1 NZ_CP042382:c2203521-2203108 [Pistricoccus aurantiacus]
MHYPIAIEVGDEQYAYSVAVPDLPGCFSAGDTFDEAIANAREAIEGHLESLAEHGDPIPTATSIEQHLADPDYAGWVWAA
VEVDMTPYLGKSHKINVTLPDLLIKRIDSRVAKQGDYQSRSGFLARAALHELERSAR

Nucleotide

• Length: 414 bp

>AT135642 NZ_CP042382:c2203521-2203108 [Pistricoccus aurantiacus]
ATGCACTATCCCATTGCCATCGAGGTTGGCGACGAGCAGTACGCCTATAGTGTTGCGGTGCCCGATCTTCCCGGCTGCTT
CTCGGCCGGCGACACCTTCGACGAGGCGATCGCCAATGCGCGCGAGGCCATCGAGGGGCACCTCGAAAGCCTGGCTGAGC
ACGGCGACCCTATTCCCACGGCGACATCGATCGAGCAGCATCTGGCCGATCCCGACTATGCAGGATGGGTATGGGCCGCG
GTCGAGGTGGACATGACGCCCTACCTGGGCAAGAGCCACAAGATCAACGTCACCCTGCCCGACCTACTGATCAAGCGCAT
CGACAGCAGGGTCGCAAAGCAAGGCGACTACCAGAGCCGTTCAGGCTTTCTCGCCCGCGCCGCGCTGCATGAATTGGAAC
GCAGCGCACGTTAG