Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5106196..5107028 Replicon chromosome
Accession NZ_CP042350
Organism Escherichia coli strain RM10410

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag FS611_RS25595 Protein ID WP_000854753.1
Coordinates 5106654..5107028 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag FS611_RS25590 Protein ID WP_001315620.1
Coordinates 5106196..5106564 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS611_RS25545 5101545..5101676 - 132 Protein_4845 IS3 family transposase -
FS611_RS25550 5101958..5102158 + 201 WP_000823256.1 hypothetical protein -
FS611_RS25555 5102367..5102492 - 126 Protein_4847 hemolysin activation protein -
FS611_RS26395 5103240..5103446 + 207 Protein_4848 autotransporter domain-containing protein -
FS611_RS25570 5103567..5105102 + 1536 WP_000939409.1 hypothetical protein -
FS611_RS25575 5105087..5105257 + 171 Protein_4850 antirestriction protein -
FS611_RS25580 5105273..5105749 + 477 WP_001186774.1 RadC family protein -
FS611_RS25585 5105812..5106033 + 222 WP_000692345.1 DUF987 domain-containing protein -
FS611_RS25590 5106196..5106564 + 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FS611_RS25595 5106654..5107028 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
FS611_RS25600 5107025..5107513 + 489 WP_000777547.1 hypothetical protein -
FS611_RS25605 5107525..5107722 + 198 WP_000839281.1 DUF957 domain-containing protein -
FS611_RS25615 5109261..5109395 + 135 Protein_4858 transcriptional regulator -
FS611_RS25635 5110339..5110989 + 651 WP_001037966.1 HNH endonuclease -
FS611_RS25640 5110997..5111977 - 981 WP_000991415.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE 5074747..5117015 42268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T135512 WP_000854753.1 NZ_CP042350:5106654-5107028 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T135512 NZ_CP042350:5106654-5107028 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT135512 WP_001315620.1 NZ_CP042350:5106196-5106564 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT135512 NZ_CP042350:5106196-5106564 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References