Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 140285..140908 Replicon chromosome
Accession NZ_CP042345
Organism Novosphingobium ginsenosidimutans strain FW-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FRF71_RS00640 Protein ID WP_147088734.1
Coordinates 140285..140650 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FRF71_RS00645 Protein ID WP_147088735.1
Coordinates 140654..140908 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRF71_RS00625 135330..136007 + 678 WP_147088731.1 phosphoribosylformylglycinamidine synthase subunit PurQ -
FRF71_RS00630 136024..138327 - 2304 WP_147088732.1 EAL domain-containing protein -
FRF71_RS00635 138446..140269 - 1824 WP_147088733.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
FRF71_RS00640 140285..140650 - 366 WP_147088734.1 type II toxin-antitoxin system VapC family toxin Toxin
FRF71_RS00645 140654..140908 - 255 WP_147088735.1 ribbon-helix-helix protein, CopG family Antitoxin
FRF71_RS00650 140951..141340 - 390 WP_202878090.1 glyoxalase -
FRF71_RS00655 141371..142723 - 1353 WP_147088736.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
FRF71_RS00660 142783..143445 + 663 WP_147088737.1 HAD-IA family hydrolase -
FRF71_RS00665 143442..145070 - 1629 WP_147088738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-41)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13709.88 Da        Isoelectric Point: 8.6208

>T135453 WP_147088734.1 NZ_CP042345:c140650-140285 [Novosphingobium ginsenosidimutans]
VSDPFFDTNILVDWLKDRAPAAAELSRYRRHRISRIVWTEVLAGEALERRDLVQQAIAPFEVVEIDARIASAAADIRHRT
RMKLLDAFILATAQVNGAILITRNTKDFPAEMPGIRVPYIL

Download         Length: 366 bp

>T135453 NZ_CP042345:c140650-140285 [Novosphingobium ginsenosidimutans]
GTGTCGGACCCGTTCTTCGATACCAACATCCTGGTCGATTGGCTCAAGGATCGCGCCCCGGCCGCGGCTGAGCTGTCGCG
CTACCGCCGCCACCGCATCAGTCGGATCGTCTGGACCGAGGTGCTGGCAGGCGAAGCCCTGGAGCGCCGCGACCTTGTTC
AGCAGGCCATCGCCCCGTTCGAAGTTGTCGAGATTGACGCGCGGATTGCCAGTGCGGCTGCGGACATTCGGCACCGCACG
CGCATGAAACTGCTCGACGCCTTTATCCTTGCCACGGCACAGGTGAACGGCGCGATCCTGATTACCCGAAACACCAAGGA
TTTCCCGGCAGAAATGCCCGGCATCCGGGTTCCCTATATCCTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9457.48 Da        Isoelectric Point: 4.8286

>AT135453 WP_147088735.1 NZ_CP042345:c140908-140654 [Novosphingobium ginsenosidimutans]
MTRILADLPEEDIKWLDARAAEQGKSRASVLRDAVSAYKAQSPADGNKDWITRGAGLWKDRQDIADGVEYQRAIRQDRTP
SEDL

Download         Length: 255 bp

>AT135453 NZ_CP042345:c140908-140654 [Novosphingobium ginsenosidimutans]
ATGACCCGCATTCTCGCCGACCTGCCCGAAGAGGATATCAAGTGGCTCGATGCTCGCGCTGCCGAACAGGGCAAGTCGCG
CGCGTCGGTGCTGCGCGATGCGGTCAGTGCCTACAAGGCGCAATCACCTGCTGACGGCAACAAGGACTGGATCACACGCG
GGGCCGGCCTGTGGAAGGATCGTCAAGACATTGCTGACGGGGTCGAATATCAACGTGCCATCCGCCAGGATCGCACCCCA
TCCGAAGACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References