Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1506251..1506847 Replicon chromosome
Accession NZ_CP042344
Organism Comamonas sp. NLF-7-7 strain NLF 7-7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FOZ74_RS07320 Protein ID WP_146912443.1
Coordinates 1506566..1506847 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag FOZ74_RS07315 Protein ID WP_146912442.1
Coordinates 1506251..1506553 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOZ74_RS07295 1502172..1502981 + 810 WP_146912439.1 cyclase family protein -
FOZ74_RS07300 1503054..1504367 + 1314 WP_146912440.1 fumarylacetoacetase -
FOZ74_RS07305 1504443..1505681 + 1239 WP_146912441.1 5-demethoxyubiquinol-8 5-hydroxylase UbiM -
FOZ74_RS07310 1505965..1506057 + 93 Protein_1418 site-specific DNA-methyltransferase -
FOZ74_RS07315 1506251..1506553 - 303 WP_146912442.1 HigA family addiction module antidote protein Antitoxin
FOZ74_RS07320 1506566..1506847 - 282 WP_146912443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOZ74_RS07325 1506896..1507192 + 297 WP_146912444.1 hypothetical protein -
FOZ74_RS07330 1507240..1510194 - 2955 WP_146912445.1 excinuclease ABC subunit UvrA -
FOZ74_RS07335 1510234..1511355 - 1122 WP_146912446.1 magnesium/cobalt transporter CorA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10737.12 Da        Isoelectric Point: 7.1677

>T135452 WP_146912443.1 NZ_CP042344:c1506847-1506566 [Comamonas sp. NLF-7-7]
MIESFASDETERLFATGKSRRLPPDILRRAVMRLAQLDAAVTVDDLRQPPSNRLEALGGDRAGQWSIRINNQWRVCFRFD
RGHAQEVEIVDYH

Download         Length: 282 bp

>T135452 NZ_CP042344:c1506847-1506566 [Comamonas sp. NLF-7-7]
ATGATCGAGAGCTTCGCCAGCGACGAAACCGAGCGCCTGTTTGCCACCGGCAAGTCGCGGCGGTTGCCCCCTGACATCCT
GCGGCGCGCGGTGATGCGGCTGGCCCAACTGGATGCCGCCGTGACGGTGGACGATCTGCGCCAGCCGCCGTCCAACCGGC
TGGAAGCGCTGGGCGGTGACCGCGCAGGGCAATGGAGCATTCGCATCAACAACCAATGGCGCGTGTGCTTCCGGTTCGAC
CGGGGCCATGCACAGGAAGTTGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10909.58 Da        Isoelectric Point: 8.5570

>AT135452 WP_146912442.1 NZ_CP042344:c1506553-1506251 [Comamonas sp. NLF-7-7]
MTTPHNGLPAIHPGEYLRETLDELGLTQTAFAQALGVSPMRVSHLLKGDRPVTAELALRLGRALSQSPQYWLNLQTSYDL
KVAQAAMKDSLKAVRELAAV

Download         Length: 303 bp

>AT135452 NZ_CP042344:c1506553-1506251 [Comamonas sp. NLF-7-7]
ATGACCACGCCCCACAACGGCCTGCCCGCCATTCACCCCGGCGAATACCTGCGCGAGACGCTGGACGAACTGGGCCTGAC
CCAGACGGCTTTTGCGCAAGCCCTGGGCGTCTCGCCCATGCGTGTATCGCACCTGCTCAAAGGGGACCGGCCCGTCACCG
CCGAGCTGGCCCTGCGCCTGGGCCGCGCCCTGAGCCAATCGCCGCAGTACTGGCTGAACCTGCAAACCAGCTACGACCTG
AAAGTGGCGCAGGCCGCCATGAAGGACAGCCTGAAGGCCGTGCGGGAACTGGCGGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References