Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1485835..1486427 Replicon chromosome
Accession NZ_CP042344
Organism Comamonas sp. NLF-7-7 strain NLF 7-7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FOZ74_RS07220 Protein ID WP_146912425.1
Coordinates 1486149..1486427 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOZ74_RS07215 Protein ID WP_146912424.1
Coordinates 1485835..1486137 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOZ74_RS07190 1481437..1482072 - 636 WP_146912419.1 VOC family protein -
FOZ74_RS07195 1482102..1483487 - 1386 WP_146912420.1 glutathione-disulfide reductase -
FOZ74_RS07200 1483662..1484225 + 564 WP_146912421.1 DUF3617 domain-containing protein -
FOZ74_RS07205 1484245..1485396 + 1152 WP_146912422.1 NnrS family protein -
FOZ74_RS07210 1485430..1485834 + 405 WP_146912423.1 phage holin family protein -
FOZ74_RS07215 1485835..1486137 - 303 WP_146912424.1 HigA family addiction module antidote protein Antitoxin
FOZ74_RS07220 1486149..1486427 - 279 WP_146912425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOZ74_RS07225 1486471..1488555 - 2085 WP_146912426.1 acetoacetate--CoA ligase -
FOZ74_RS07230 1488709..1489134 + 426 WP_146912427.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10585.23 Da        Isoelectric Point: 10.3067

>T135451 WP_146912425.1 NZ_CP042344:c1486427-1486149 [Comamonas sp. NLF-7-7]
MILDFRCSDTKALFEQKRVARFVAIEAVALRRLAQLHAATSLDFLRVPPGNRLEALRGDRKGQYSIRINSQWRLCFLWSD
GHASQVEIVGYH

Download         Length: 279 bp

>T135451 NZ_CP042344:c1486427-1486149 [Comamonas sp. NLF-7-7]
ATGATCCTCGATTTCCGCTGTTCGGACACGAAAGCGCTCTTCGAGCAAAAAAGGGTGGCGCGTTTCGTCGCCATTGAAGC
GGTGGCGCTGCGGCGCCTGGCGCAACTGCACGCGGCGACATCGCTGGACTTCTTGCGCGTGCCGCCAGGCAATCGGCTGG
AGGCGCTGCGCGGCGACCGCAAAGGCCAATACAGCATCCGCATCAACAGCCAGTGGCGCTTGTGCTTCCTCTGGTCGGAC
GGGCACGCTAGCCAGGTCGAGATCGTCGGCTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11298.88 Da        Isoelectric Point: 9.6945

>AT135451 WP_146912424.1 NZ_CP042344:c1486137-1485835 [Comamonas sp. NLF-7-7]
MTTHPQWPHPGEILQEDFLVPMGISQYRIAKAIGVPARRINEIVKGQRGITADTALRLAAFFGTEAQSWLNLQSEYDLRR
ARQSMREALAAIERYSTQSA

Download         Length: 303 bp

>AT135451 NZ_CP042344:c1486137-1485835 [Comamonas sp. NLF-7-7]
ATGACCACGCATCCCCAATGGCCCCATCCGGGCGAGATCCTGCAGGAAGACTTTCTCGTCCCCATGGGCATCAGCCAGTA
CCGCATCGCCAAGGCGATTGGCGTGCCTGCGCGTCGCATCAACGAAATCGTCAAGGGGCAGCGCGGCATCACCGCCGATA
CCGCGCTGCGCCTGGCGGCGTTTTTCGGCACCGAGGCGCAGAGCTGGCTCAACTTGCAGAGCGAGTACGACCTGCGCCGG
GCACGCCAGTCGATGCGCGAGGCGCTGGCCGCAATAGAGCGCTATTCGACACAAAGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References