Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 295000..295615 Replicon chromosome
Accession NZ_CP042344
Organism Comamonas sp. NLF-7-7 strain NLF 7-7

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FOZ74_RS01465 Protein ID WP_146911344.1
Coordinates 295000..295281 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOZ74_RS01470 Protein ID WP_146911346.1
Coordinates 295307..295615 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOZ74_RS01430 290652..290858 + 207 WP_146911333.1 addiction module antitoxin -
FOZ74_RS01435 291191..291682 + 492 WP_146911335.1 helix-turn-helix transcriptional regulator -
FOZ74_RS01440 291679..292104 + 426 WP_146911336.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FOZ74_RS16015 292718..292885 - 168 WP_186764631.1 hypothetical protein -
FOZ74_RS01450 292979..293479 - 501 WP_146914031.1 pilin -
FOZ74_RS01455 293758..294315 + 558 WP_146911340.1 hypothetical protein -
FOZ74_RS01460 294516..294905 + 390 WP_146911342.1 transcriptional regulator -
FOZ74_RS01465 295000..295281 + 282 WP_146911344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOZ74_RS01470 295307..295615 + 309 WP_146911346.1 HigA family addiction module antidote protein Antitoxin
FOZ74_RS01475 295783..296202 - 420 WP_146911347.1 type II toxin-antitoxin system MqsA family antitoxin -
FOZ74_RS01480 296204..296350 - 147 WP_146911348.1 type II toxin-antitoxin system MqsR family toxin -
FOZ74_RS01485 296430..296750 - 321 WP_146911350.1 DNA-binding transcriptional regulator -
FOZ74_RS01490 296747..297118 - 372 Protein_283 type II toxin-antitoxin system RelE/ParE family toxin -
FOZ74_RS01495 297252..297611 + 360 Protein_284 PIN domain-containing protein -
FOZ74_RS01500 297809..298057 + 249 WP_146911352.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOZ74_RS01505 298047..298328 + 282 WP_146911353.1 type II toxin-antitoxin system RelE/ParE family toxin -
FOZ74_RS01510 298546..299022 - 477 WP_146911355.1 phage virion morphogenesis protein -
FOZ74_RS01515 299156..300082 - 927 WP_146911357.1 hypothetical protein -
FOZ74_RS01520 300082..300390 - 309 WP_146911358.1 HigA family addiction module antidote protein -
FOZ74_RS01525 300400..300513 - 114 WP_146911360.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 289863..298328 8465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10695.22 Da        Isoelectric Point: 10.1076

>T135446 WP_146911344.1 NZ_CP042344:295000-295281 [Comamonas sp. NLF-7-7]
MPIVSFRCPDTQRLFTSGKTRRFSSFQSVAERKLAQLDAAVTLDFLRSPPGNRLELLTGDRQGQHSIRINGQWRVCFVWT
DKGPMNVEIVDYH

Download         Length: 282 bp

>T135446 NZ_CP042344:295000-295281 [Comamonas sp. NLF-7-7]
ATGCCCATTGTTTCCTTCAGGTGCCCAGACACTCAGCGCTTGTTCACCAGCGGCAAGACACGGCGTTTTTCCAGCTTCCA
GTCTGTGGCAGAGCGCAAGCTGGCACAACTGGATGCCGCCGTGACACTGGATTTTTTGCGCAGTCCGCCAGGCAATCGCC
TTGAGCTGCTGACGGGCGACCGCCAAGGGCAGCACAGCATCCGCATCAACGGCCAGTGGCGCGTGTGCTTTGTCTGGACG
GACAAAGGGCCCATGAATGTGGAAATCGTCGACTATCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11267.03 Da        Isoelectric Point: 9.1116

>AT135446 WP_146911346.1 NZ_CP042344:295307-295615 [Comamonas sp. NLF-7-7]
MVKNGMRPIHPGEILREDYLKPLQLSANALAGQLHVPASRINDIVLGRRGITADTALRLCRFFGGDARSWLNLQTAYDLR
VAELDGAVQQAVQTVHPMLHPT

Download         Length: 309 bp

>AT135446 NZ_CP042344:295307-295615 [Comamonas sp. NLF-7-7]
ATGGTCAAAAACGGCATGCGCCCCATCCACCCGGGCGAAATATTGCGTGAGGACTACCTCAAACCTCTGCAGCTCAGCGC
CAATGCGCTGGCCGGGCAACTGCACGTACCTGCATCGCGCATCAACGACATCGTGCTGGGGCGCCGGGGCATTACCGCCG
ATACGGCCTTGCGCCTGTGCCGCTTTTTTGGGGGTGACGCACGGTCATGGCTCAATCTGCAAACGGCTTACGATTTGCGC
GTGGCCGAGCTTGACGGGGCAGTGCAACAGGCCGTGCAGACGGTGCACCCCATGCTGCATCCGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References