Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 866866..867431 Replicon chromosome
Accession NZ_CP042300
Organism Vibrio cholerae O1 strain AAS91

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag FKV26_RS17375 Protein ID WP_000869999.1
Coordinates 866866..867153 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag FKV26_RS17380 Protein ID WP_000086649.1
Coordinates 867150..867431 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKV26_RS17335 862265..862780 - 516 WP_001201532.1 lipocalin family protein -
FKV26_RS17340 862807..862899 - 93 WP_014164112.1 DUF3265 domain-containing protein -
FKV26_RS18975 862921..863499 - 579 WP_000110120.1 hypothetical protein -
FKV26_RS17345 863728..863970 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
FKV26_RS17350 863967..864266 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
FKV26_RS17355 864397..864912 - 516 WP_000100089.1 ClbS/DfsB family four-helix bundle protein -
FKV26_RS17360 865107..865289 - 183 WP_001889223.1 DUF645 family protein -
FKV26_RS17365 865584..866033 - 450 WP_000480555.1 hypothetical protein -
FKV26_RS17370 866168..866707 - 540 WP_000884561.1 hydrolase -
FKV26_RS17375 866866..867153 - 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FKV26_RS17380 867150..867431 - 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FKV26_RS17385 867645..868070 - 426 WP_000735184.1 hypothetical protein -
FKV26_RS17400 868889..869170 - 282 WP_080033523.1 DUF1289 domain-containing protein -
FKV26_RS18980 869119..869232 - 114 WP_080033520.1 acetyltransferase -
FKV26_RS17405 869289..869840 - 552 WP_001008561.1 VRR-NUC domain-containing protein -
FKV26_RS17410 870111..870434 - 324 WP_080033519.1 DUF3709 domain-containing protein -
FKV26_RS17415 870566..871234 - 669 WP_000852842.1 hypothetical protein -
FKV26_RS17420 871392..871754 - 363 WP_170831679.1 DUF4144 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 827249..947639 120390
- inside Integron - - 828494..941258 112764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T135203 WP_000869999.1 NZ_CP042300:c867153-866866 [Vibrio cholerae O1]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T135203 NZ_CP042300:c867153-866866 [Vibrio cholerae O1]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT135203 WP_000086649.1 NZ_CP042300:c867431-867150 [Vibrio cholerae O1]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT135203 NZ_CP042300:c867431-867150 [Vibrio cholerae O1]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1


Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References