Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4210227..4210485 Replicon chromosome
Accession NZ_CP042246
Organism Escherichia coli strain PU-1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FQU83_RS22690 Protein ID WP_000809168.1
Coordinates 4210333..4210485 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4210227..4210284 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU83_RS22675 4206059..4207318 - 1260 WP_000494924.1 hypothetical protein -
FQU83_RS22680 4207447..4208940 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
FQU83_RS22685 4208960..4209721 - 762 WP_001274823.1 hypothetical protein -
- 4210227..4210284 - 58 - - Antitoxin
FQU83_RS22690 4210333..4210485 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
FQU83_RS22695 4210590..4211720 - 1131 WP_001118464.1 molecular chaperone DnaJ -
FQU83_RS22700 4211809..4213725 - 1917 WP_000516135.1 molecular chaperone DnaK -
FQU83_RS22705 4214097..4214501 + 405 WP_000843687.1 DUF2541 family protein -
FQU83_RS22710 4214527..4215240 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T135062 WP_000809168.1 NZ_CP042246:4210333-4210485 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T135062 NZ_CP042246:4210333-4210485 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT135062 NZ_CP042246:c4210284-4210227 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References