Detailed information of TA system TA134523

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1976314..1976774
• Replicon: chromosome
• Accession: NZ_CP041875
• Organism: Mycobacterium tuberculosis strain 1-0007P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TKL9
• Locus tag: FPJ31_RS09145
• Protein ID: WP_003898996.1
• Coordinates: 1976526..1976774 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ31_RS09140
• Protein ID: WP_193070314.1
• Coordinates: 1976314..1976526 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ31_RS09125	1972792..1973979	-	1188	WP_003898992.1	nitrate transporter NarK	-
FPJ31_RS09130	1974266..1974550	+	285	WP_003408522.1	DUF1876 domain-containing protein	-
FPJ31_RS09135	1974564..1976246	-	1683	WP_003898994.1	SulP family inorganic anion transporter	-
FPJ31_RS09140	1976314..1976526	+	213	WP_193070314.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPJ31_RS09145	1976526..1976774	+	249	WP_003898996.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ31_RS09150	1976782..1977519	+	738	WP_003898997.1	hypothetical protein	-
FPJ31_RS09155	1977613..1979313	+	1701	WP_003898998.1	serine/threonine protein kinase PknE	-
FPJ31_RS09160	1979598..1979999	-	402	WP_003408538.1	hypothetical protein	-
FPJ31_RS09165	1979989..1980600	-	612	WP_003898999.1	isopentenyl-diphosphate Delta-isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8884.14 Da
• Isoelectric Point: 4.1074

>T134523 WP_003898996.1 NZ_CP041875:1976526-1976774 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T134523 NZ_CP041875:1976526-1976774 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7589.77 Da
• Isoelectric Point: 9.3146

>AT134523 WP_193070314.1 NZ_CP041875:1976314-1976526 [Mycobacterium tuberculosis]
MELAARIGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Nucleotide

• Length: 213 bp

>AT134523 NZ_CP041875:1976314-1976526 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATAGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Structures

Toxin

• AlphaFold DB: G0TKL9